Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.53 |
| ▸ | TACR2 | P21452 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SHBG | P04278 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL283112 | 1.00 | CA2 (0.66) | CA2SMN1; SMN2LMNAHTTESR1 | |
| SCHEMBL283020 | 1.00 | CA2 (0.66) | CA2SMN1; SMN2LMNAHTTESR1 | |
| SCHEMBL282368 | 1.00 | CA2 (0.66) | CA2SMN1; SMN2LMNAHTTESR1 | |
| SCHEMBL10607986 | 1.00 | CA2 (0.66) | CA2SMN1; SMN2LMNAHTTESR1 | |
| SCHEMBL282149 | 1.00 | CA2 (0.66) | CA2SMN1; SMN2LMNAHTTESR1 | |
| SCHEMBL10610516 | 1.00 | CA2 (0.66) | CA2SMN1; SMN2LMNAHTTESR1 | |
| SCHEMBL3684557 | 1.00 | CA2 (0.66) | CA2SMN1; SMN2LMNAHTTESR1 | |
| SCHEMBL10609781 | 1.00 | CA2 (0.66) | CA2SMN1; SMN2LMNAHTTESR1 | |
| SCHEMBL282436 | 1.00 | CA2 (0.66) | CA2SMN1; SMN2LMNAHTTESR1 | |
| SCHEMBL10608015 | 1.00 | CA2 (0.66) | CA2SMN1; SMN2LMNAHTTESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220273659-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | NUVATION BIO OPERATING COMPANY LLC | 2022-09-01 | — | — | US | disclosed |
| EP-3993802-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Nuvation Bio Inc. (US) | 2022-05-11 | — | — | EP | disclosed |
| CN-114340634-A | Heterocyclic compounds as kinase inhibitors | 诺维逊生物股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| WO-2021003314-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | NUVATION BIO INC. (US) | 2021-01-07 | — | — | WO | disclosed |
| US-10292972-B1 | Pharmaceutical composition for treating cancer and a method thereof | KING ABDULAZIZ UNIVERSITY (SA) | 2019-05-21 | — | — | US | disclosed |
| US-20190125732-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING CANCER AND A METHOD THEREOF | KING ABDULAZIZ UNIVERSITY (SA) | 2019-05-02 | — | — | US | disclosed |
| EP-2428504-B1 | Small molecule inhibitors of the pleckstrin homology domain and method for using same | UNIV TEXAS (US) | 2017-05-17 | — | — | EP | disclosed |
| US-9320734-B2 | Small molecule inhibitors of the pleckstrin homology domain and methods for using same | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-04-26 | — | — | US | disclosed |
| US-20150126563-A1 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-05-07 | — | — | US | disclosed |
| US-8962663-B2 | Small molecule inhibitors of the pleckstrin homology domain and methods for using same | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-02-24 | — | — | US | disclosed |
| US-20110144066-A1 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-06-16 | — | — | US | disclosed |
| WO-2011032169-A2 | PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS INCLUDING INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | PHUSIS THERAPEUTICS INC. (US) | 2011-03-17 | — | — | WO | disclosed |
| EP-2291349-A2 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | The Board of Regents of The University of Texas System (US) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009129267-A2 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-10-22 | — | — | WO | disclosed |
| US-20030229113-A1 | Keratinocyte growth inhibitors and hydroxamic acid derivatives | AKZO NOBEL N.V. (NL) | 2003-12-11 | — | — | US | disclosed |
| US-5750506-A | TREATING INFLAMMATION, HEAD TRAUMA, PAIN, ASTHMA | CORTECH, INC. (US) | 1998-05-12 | — | — | US | disclosed |
| EP-0360521-B1 | Achiral fluorine-containing liquid crystals | MINNESOTA MINING & MFG (US) | 1993-11-24 | — | — | EP | disclosed |
| US-5082587-A | ACHIRAL FLUORINE-CONTAINING LIQUID CRYSTALS | 3M INNOVATIVE PROPERTIES COMPANY | 1992-01-21 | — | — | US | disclosed |
| EP-0360521-A2 | Achiral fluorine-containing liquid crystals | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1990-03-28 | — | — | EP | disclosed |
| US-4874894-A | Process for the production of benzenesulfonamides | HILTON DAVIS CO. (US) | 1989-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144066-A1 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | PLEKHG3, PLEKHA1, PLEC | CA2 3465/4885SMN1; SMN2 1984/4885LMNA 2456/4885 |
| US-20150126563-A1 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | PLEKHG3, PLEKHA1, PLEC | CA2 3465/4885SMN1; SMN2 1984/4885LMNA 2456/4885 |
| US-20030229113-A1 | Keratinocyte growth inhibitors and hydroxamic acid derivatives | FGF1, FGF2, EGFR | CA2 252/4885SMN1; SMN2 4634/4885LMNA 2763/4885 |
| US-10292972-B1 | Pharmaceutical composition for treating cancer and a method thereof | SYMPK, ITPA, HRAS | CA2 383/4885SMN1; SMN2 4534/4885LMNA 3901/4885 |
| US-20190125732-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING CANCER AND A METHOD THEREOF | SYMPK, ITPA, HRAS | CA2 383/4885SMN1; SMN2 4534/4885LMNA 3901/4885 |
| US-20220273659-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | CDK4, CDK6, CDK8 | CA2 4392/4885SMN1; SMN2 2917/4885LMNA 3004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.