Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
| ▸ | DHFR | P00374 | 3/20 | 0.35 |
| ▸ | AR | P10275 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2825595 | 0.84 | P4HB (0.36) | ACACBDHFRARALDH1A1MAPT | |
| SCHEMBL2827409 | 0.82 | GRM5 (0.47) | — | |
| SCHEMBL2070877 | 0.77 | PPARA (0.43) | ACACBALDH1A1MAPTACHE | |
| SCHEMBL2820978 | 0.72 | GRM5 (0.44) | KDR | |
| SCHEMBL2825829 | 0.71 | GRM5 (0.43) | ACACBALDH1A1MAPT | |
| SCHEMBL16641175 | 0.71 | CA2 (0.54) | ACACBARALDH1A1HTR3AACHE | |
| SCHEMBL14176700 | 0.69 | AR (0.44) | ARALDH1A1MAPTACHEPDGFRB | |
| SCHEMBL30832957 | 0.69 | CA2 (0.52) | DHFRARALDH1A1MAPTHTR1A | |
| SCHEMBL7859196 | 0.69 | CA2 (0.52) | DHFRARALDH1A1MAPTHTR1A | |
| SCHEMBL2821756 | 0.69 | GRM5 (0.41) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745003-B1 | NOVEL COMPOUNDS, THEIR PREPARATION AND USE | HIGH POINT PHARMACEUTICALS LLC (US) | 2010-10-27 | — | — | EP | claimed |