Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | XBP1 | P17861 | 3/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TERT | O14746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20376172 | 0.90 | NPC1 (0.57) | NPC1MAPTHTTRAB9AXBP1 | |
| Chamissonolide SCHEMBL23601535 | 0.90 | NPC1 (0.52) | NPC1MAPTHTTRAB9AXBP1 | |
| SCHEMBL29096257 | 0.84 | NPC1 (0.59) | NPC1MAPTHTTRAB9AXBP1 | |
| SCHEMBL16677163 | 0.84 | NPC1 (0.59) | NPC1MAPTHTTRAB9AXBP1 | |
| SCHEMBL16639615 | 0.78 | NPC1 (0.62) | NPC1MAPTHTTRAB9AXBP1 | |
| SCHEMBL20953522 | 0.77 | NPC1 (0.47) | NPC1MAPTHTTRAB9AXBP1 | |
| SCHEMBL16641594 | 0.76 | NPC1 (0.60) | NPC1MAPTHTTRAB9AXBP1 | |
| SCHEMBL16644430 | 0.75 | NPC1 (0.59) | NPC1MAPTHTTRAB9AXBP1 | |
| SCHEMBL20953521 | 0.70 | PTGS2 (0.33) | PTGS2 | |
| SCHEMBL23266629 | 0.69 | MAPT (0.67) | NPC1MAPTHTTRAB9AXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109022353-B | Bone morphogenetic protein 2 activator and application thereof in promoting osteogenic differentiation of mesenchymal stem cells | 山东兴瑞生物科技有限公司 | 2021-11-02 | — | — | CN | disclosed |
| CN-109022354-B | Vascular endothelial growth factor 165 activator and application thereof in stem cells | 广东创晟控股集团有限公司 | 2021-10-01 | — | — | CN | disclosed |
| CN-108913658-B | Bone morphogenetic protein 2 activator for inducing stem cell directional differentiation | 广东创晟控股集团有限公司 | 2021-10-01 | — | — | CN | disclosed |
| CN-108913657-B | VEGF-165 activator and application thereof in promoting stem cell differentiation | 深圳华源再生医学有限公司 | 2021-07-06 | — | — | CN | disclosed |
| CN-109055307-B | BMP-2 activator and application thereof in stem cell induced differentiation | 杭州爱唯生命科技有限公司 | 2021-06-11 | — | — | CN | disclosed |
| CN-109055307-A | A kind of BMP-2 activator and the application in terms of stem cell induces differentiation | 青海七彩花生物科技有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-109022353-A | A kind of bone morphogenetic protein 2 activator and the purposes for promoting mescenchymal stem cell Osteoblast Differentiation | 青海七彩花生物科技有限公司 | 2018-12-18 | — | — | CN | disclosed |
| CN-109022354-A | A kind of vascular endothelial growth factor 165 activator and the application in stem cell | 青海七彩花生物科技有限公司 | 2018-12-18 | — | — | CN | disclosed |