Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.47 |
| ▸ | XBP1 | P17861 | 3/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20376172 | 0.87 | NPC1 (0.57) | NPC1MAPTHTTRAB9AMAPK1 | |
| Inuchinenolide C SCHEMBL28264096 | 0.77 | NPC1 (0.51) | NPC1MAPTHTTRAB9AMAPK1 | |
| SCHEMBL16677163 | 0.76 | NPC1 (0.59) | NPC1MAPTHTTRAB9AMAPK1 | |
| SCHEMBL29096257 | 0.76 | NPC1 (0.59) | NPC1MAPTHTTRAB9AMAPK1 | |
| SCHEMBL16639615 | 0.72 | NPC1 (0.62) | NPC1MAPTHTTRAB9AMAPK1 | |
| SCHEMBL16641594 | 0.71 | NPC1 (0.60) | NPC1MAPTHTTRAB9AMAPK1 | |
| SCHEMBL16644430 | 0.70 | NPC1 (0.59) | NPC1MAPTHTTRAB9AMAPK1 | |
| Chamissonolide SCHEMBL23601535 | 0.70 | NPC1 (0.52) | NPC1MAPTHTTRAB9AMAPK1 | |
| Ergolide SCHEMBL28262978 | 0.65 | PTGS2 (0.67) | NPC1MAPTHTTRAB9AMAPK1 | |
| Bigelovin SCHEMBL29349709 | 0.64 | MAPT (1.00) | NPC1MAPTHTTRAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10273220-B2 | Derivative of Inula lineariifolia lactone A | SHANXI ZHENDONG LEADING BIOTECHNOLOGY CO., LTD. (TW) | 2019-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10273220-B2 | Derivative of Inula lineariifolia lactone A | INMT, SIRT5, INPP5A | NPC1 3040/4885MAPT 836/4885HTT 3528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.