Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224 | 0.79 | — | — | |
| SCHEMBL9499016 | 0.78 | CALM1 (0.60) | SLC6A2SLC6A4SLC6A3HDAC1HDAC8 | |
| SCHEMBL27462691 | 0.78 | CALM1 (0.60) | LMNATSHRHTR2ATAAR1 | |
| SCHEMBL28377926 | 0.77 | CALM1 (0.50) | HDAC8HDAC6TSHRHTR2AMEN1 | |
| SCHEMBL29073219 | 0.77 | CALM1 (0.50) | HDAC8HDAC6TSHRHTR2AMEN1 | |
| SCHEMBL11139354 | 0.76 | CYP3A4 (0.42) | TSHRKMT2A | |
| SCHEMBL1271150 | 0.76 | TAAR1 (0.50) | LMNATSHRMEN1KMT2ATAAR1 | |
| SCHEMBL27672051 | 0.76 | MAOA (0.50) | HDAC1HTR2ATAAR1 | |
| SCHEMBL8023647 | 0.76 | PGK1 (0.36) | LMNATSHRHTR2AMEN1KMT2A | |
| Diphenylmethane SCHEMBL11228811 | 0.75 | CALM1 (0.50) | SLC6A2SLC6A4SLC6A3HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108977446-A | The RNAi reagent of modification | 阿尔尼拉姆医药品有限公司 | 2018-12-11 | — | — | CN | disclosed |