Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.34 |
| ▸ | BMP2K | Q9NSY1 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830130 | 0.89 | FAAH (0.44) | ALDH1A1SMN1; SMN2GRM5MAPTCYP1A2 | |
| SCHEMBL2825994 | 0.88 | CHRNB2 (0.40) | GAASMN1; SMN2GRM5MEN1KMT2A | |
| SCHEMBL2830024 | 0.84 | ALDH1A1 (0.42) | ALDH1A1GAASMN1; SMN2GRM5MAPT | |
| SCHEMBL2826665 | 0.82 | HPGD (0.50) | ALDH1A1SMN1; SMN2MAPTHPGDMEN1 | |
| SCHEMBL2831279 | 0.81 | RAB9A (0.41) | ALDH1A1GAASMN1; SMN2GRM5MAPT | |
| SCHEMBL2827177 | 0.79 | ALDH1A1 (0.46) | ALDH1A1GAAGRM5MEN1CYP1A2 | |
| SCHEMBL2828853 | 0.78 | KMT2A (0.43) | SMN1; SMN2GRM5MAPTMEN1KMT2A | |
| SCHEMBL2827571 | 0.78 | LMNA (0.47) | ALDH1A1SMN1; SMN2HPGDMEN1CYP3A4 | |
| SCHEMBL2828820 | 0.77 | KMT2A (0.42) | ALDH1A1GAASMN1; SMN2GRM5MAPT | |
| SCHEMBL2825286 | 0.76 | GRM5 (0.37) | ALDH1A1GAAGRM5MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |