Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827571 | 0.88 | LMNA (0.47) | RAB9AALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL2828853 | 0.88 | KMT2A (0.43) | RAB9ASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2826665 | 0.87 | HPGD (0.50) | RAB9AALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL2828820 | 0.87 | KMT2A (0.42) | RAB9AALDH1A1SMN1; SMN2GAAMEN1 | |
| SCHEMBL2832758 | 0.82 | ALDH1A1 (0.47) | RAB9AALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL2830130 | 0.81 | FAAH (0.44) | RAB9AALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL2826533 | 0.81 | ALDH1A1 (0.39) | RAB9AALDH1A1SMN1; SMN2GAAMEN1 | |
| SCHEMBL2829854 | 0.80 | SMN1; SMN2 (0.44) | RAB9AALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL2825994 | 0.80 | CHRNB2 (0.40) | RAB9ALMNASMN1; SMN2GAAMEN1 | |
| SCHEMBL2827539 | 0.79 | NAMPT (0.45) | RAB9AALDH1A1LMNASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |