Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GCK | P35557 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826011 | 0.84 | ALDH1A1 (0.41) | NPC1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2828968 | 0.83 | MAPT (0.44) | NPC1SMN1; SMN2MAPTALDH1A1RAB9A | |
| SCHEMBL2828877 | 0.80 | RAB9A (0.52) | NPC1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2827802 | 0.78 | SCD (0.48) | NPC1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2829552 | 0.78 | RAB9A (0.47) | NPC1KMT2ASMN1; SMN2MAPTRAB9A | |
| SCHEMBL2830217 | 0.77 | RAB9A (0.41) | NPC1SMN1; SMN2MAPTALDH1A1RAB9A | |
| SCHEMBL2824997 | 0.76 | GRM5 (0.48) | NPC1SMN1; SMN2MAPTRAB9AHPGD | |
| SCHEMBL11183549 | 0.74 | MAPT (0.57) | NPC1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2830832 | 0.74 | ALDH1A1 (0.49) | NPC1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2827794 | 0.73 | CHRNB2 (0.45) | NPC1SMN1; SMN2MAPTRAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |