Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.47 |
| ▸ | NPC1 | O15118 | 10/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GCK | P35557 | 3/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | SCD | O00767 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827187 | 0.84 | LCK (0.45) | RAB9ANPC1POLBGRM5MAPT | |
| SCHEMBL2828877 | 0.84 | RAB9A (0.52) | RAB9ANPC1POLBGCKSCD | |
| SCHEMBL2827802 | 0.82 | SCD (0.48) | RAB9ANPC1POLBGCKSCD | |
| SCHEMBL2830217 | 0.80 | RAB9A (0.41) | RAB9ANPC1GRM5NPSR1SMN1; SMN2 | |
| SCHEMBL2828965 | 0.80 | ALDH1A1 (0.46) | POLBNPSR1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL2824997 | 0.79 | GRM5 (0.48) | RAB9ANPC1POLBGRM5SMN1; SMN2 | |
| SCHEMBL2830126 | 0.78 | NPC1 (0.42) | RAB9ANPC1POLBGCKGRM5 | |
| SCHEMBL2828968 | 0.78 | MAPT (0.44) | RAB9ANPC1POLBGRM5SMN1; SMN2 | |
| SCHEMBL2828532 | 0.78 | NPC1 (0.44) | RAB9ANPC1POLBGCKGRM5 | |
| SCHEMBL2833374 | 0.77 | CHRNB2 (0.36) | GRM5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |