Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.39 |
| ▸ | CPA3 | P15088 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.37 |
| ▸ | GGH | Q92820 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | EPOR | P19235 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11185212 | 0.99 | LMNA (0.41) | LMNATDP1HSD17B10FOLH1CPA3 | |
| SCHEMBL6065012 | 0.99 | LMNA (0.41) | LMNATDP1HSD17B10FOLH1CPA3 | |
| SCHEMBL28287517 | 0.97 | LMNA (0.40) | LMNATDP1HSD17B10FOLH1CPA3 | |
| SCHEMBL28286136 | 0.97 | NR4A2 (0.41) | LMNATDP1HSD17B10FOLH1CPA3 | |
| SCHEMBL5498422 | 0.81 | CTRB1 (0.41) | LMNATDP1FOLH1CPA3ALDH1A1 | |
| SCHEMBL7211709 | 0.80 | FOLH1 (0.37) | LMNATDP1HSD17B10FOLH1CPA3 | |
| SCHEMBL28129661 | 0.79 | FOLH1 (0.47) | LMNATDP1HSD17B10FOLH1CPA3 | |
| SCHEMBL28129663 | 0.79 | FOLH1 (0.47) | LMNATDP1HSD17B10FOLH1CPA3 | |
| SCHEMBL10771734 | 0.79 | ALDH1A1 (0.43) | LMNAALDH1A1HDAC1 | |
| SCHEMBL1083608 | 0.76 | CPA3 (0.42) | LMNATDP1HSD17B10FOLH1CPA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109553619-A | A kind of preparation method of methotrexate (MTX) | 北京斯利安药业有限公司 | 2019-04-02 | — | — | CN | claimed |
| CN-109553619-A | A kind of preparation method of methotrexate (MTX) | 北京斯利安药业有限公司 | 2019-04-02 | — | — | CN | disclosed |
| CN-109553619-A | A kind of preparation method of methotrexate (MTX) | 北京斯利安药业有限公司 | 2019-04-02 | — | — | CN | disclosed |