Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Glutamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.30 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 3/20 | 0.30 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL20641479 | 0.89 | GSR (0.48) | GSRSLC7A5THRBCPB2DPP4 | |
| Lysine SCHEMBL4450695 | 0.89 | GSR (0.48) | GSRSLC7A5THRBCPB2DPP4 | |
| Lysine SCHEMBL29253065 | 0.89 | GSR (0.48) | GSRSLC7A5THRBCPB2DPP4 | |
| Glutamine SCHEMBL16581535 | 0.88 | GSR (0.49) | GSRALOX15BLMPMP22KMT2A | |
| Glutamine SCHEMBL3987641 | 0.88 | ALOX15 (0.46) | GSRALOX15BLMPMP22KMT2A | |
| Lysine SCHEMBL8561773 | 0.87 | GSR (0.46) | GSRTHRBCPB2DPP4DPP7 | |
| Lysine SCHEMBL20678166 | 0.87 | GSR (0.50) | GSRCPB2DPP4DPP7DPP8 | |
| Glutamine SCHEMBL28366405 | 0.87 | GSR (0.34) | GSRALOX15BLMPMP22KMT2A | |
| Lysine SCHEMBL9167629 | 0.86 | GSR (0.36) | GSRSLC7A5 | |
| Glutamine SCHEMBL4294114 | 0.86 | ALOX15 (0.42) | GSRALOX15BLMPMP22KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109694409-A | A kind of angiotensin converting enzyme inhibition activity Functional Polypeptides and its application | 中国科学院南海海洋研究所 | 2019-04-30 | — | — | CN | claimed |