Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.38 |
| ▸ | RHEB | Q15382 | 7/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | DDO | Q99489 | 1/20 | 0.37 |
| ▸ | CTSV | O60911 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 2/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27906754 | 0.82 | DAO (0.44) | MTNR1AMTNR1BRHEBDAODDO | |
| SCHEMBL27965811 | 0.81 | PARP1 (0.40) | MTNR1AMTNR1BRHEBCTSVCTSL | |
| SCHEMBL27491895 | 0.81 | DAO (0.43) | MTNR1AMTNR1BDAODDOCTSV | |
| SCHEMBL27524233 | 0.81 | DAO (0.43) | MTNR1AMTNR1BRHEBDAOKDM4E | |
| SCHEMBL27486903 | 0.80 | MTNR1A (0.32) | MTNR1AMTNR1BDAODDO | |
| SCHEMBL28293158 | 0.79 | MTNR1A (0.39) | MTNR1AMTNR1BRHEBALDH1A1KDM4E | |
| SCHEMBL28678160 | 0.78 | MTNR1A (0.58) | MTNR1AMTNR1BKDM4EMEN1KMT2A | |
| SCHEMBL27704235 | 0.76 | HRH4 (0.40) | MTNR1AMTNR1BALDH1A1MEN1KMT2A | |
| SCHEMBL27488329 | 0.74 | LOXL2 (0.50) | MTNR1AMTNR1B | |
| SCHEMBL28293162 | 0.74 | JAK2 (0.46) | MTNR1AMTNR1BALDH1A1KDM4ENR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109748840-A | A kind of synthetic method of 2- substituted indole derivative | 中国医学科学院药物研究所 | 2019-05-14 | — | — | CN | disclosed |