Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.39 |
| ▸ | RHEB | Q15382 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 10/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.34 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27965811 | 0.81 | PARP1 (0.40) | MTNR1AMTNR1BRHEBPARP1 | |
| SCHEMBL27906754 | 0.80 | DAO (0.44) | MTNR1AMTNR1BRHEBKDM4EALDH1A1 | |
| SCHEMBL28291601 | 0.79 | MTNR1A (0.38) | MTNR1AMTNR1BRHEBKDM4EALDH1A1 | |
| SCHEMBL27524233 | 0.79 | DAO (0.43) | MTNR1AMTNR1BRHEBKDM4E | |
| SCHEMBL27491895 | 0.79 | DAO (0.43) | MTNR1AMTNR1B | |
| SCHEMBL28678160 | 0.76 | MTNR1A (0.58) | MTNR1AMTNR1BKDM4E | |
| SCHEMBL27704235 | 0.74 | HRH4 (0.40) | MTNR1AMTNR1BALDH1A1GAAPARP1 | |
| SCHEMBL28291602 | 0.73 | MTNR1A (0.38) | MTNR1AMTNR1BPKN2PKN1 | |
| SCHEMBL28872616 | 0.73 | MMP2 (0.48) | MTNR1AMTNR1B | |
| SCHEMBL27488329 | 0.72 | LOXL2 (0.50) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109748840-A | A kind of synthetic method of 2- substituted indole derivative | 中国医学科学院药物研究所 | 2019-05-14 | — | — | CN | disclosed |