Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 5/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27491895 | 0.78 | DAO (0.43) | MTNR1AMTNR1BMCL1NR3C1PGR | |
| SCHEMBL27906754 | 0.77 | DAO (0.44) | MTNR1AMTNR1BKDM4EALDH1A1HPGD | |
| SCHEMBL28168776 | 0.77 | FBP1 (0.48) | MTNR1AMTNR1BKDM4EHSD17B10HTT | |
| SCHEMBL28678160 | 0.76 | MTNR1A (0.58) | MTNR1AMTNR1BKDM4ESMN1; SMN2HTT | |
| SCHEMBL28880746 | 0.76 | PTGS2 (0.45) | MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL27965811 | 0.76 | PARP1 (0.40) | MTNR1AMTNR1B | |
| SCHEMBL27524233 | 0.76 | DAO (0.43) | MTNR1AMTNR1BKDM4EHPGD | |
| SCHEMBL28291608 | 0.75 | MMP2 (0.50) | MTNR1AMTNR1BKDM4EALDH1A1HPGD | |
| SCHEMBL28293142 | 0.75 | MMP2 (0.40) | MTNR1AMTNR1BKDM4EALDH1A1HPGD | |
| SCHEMBL28291601 | 0.74 | MTNR1A (0.38) | MTNR1AMTNR1BKDM4EALDH1A1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109748840-A | A kind of synthetic method of 2- substituted indole derivative | 中国医学科学院药物研究所 | 2019-05-14 | — | — | CN | disclosed |