SCHEMBL28293120

SCHEMBL28293120

C[SiH](C)[C@@]1(n2cc(C(C)(C)C)c(=O)[nH]c2=O)O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.36
ALOX12 P18054 1/20 0.36
ADRA1A P35348 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
PYGM P11217 3/20 0.34
TK2 O00142 3/20 0.33
TK1 P04183 1/20 0.33
PYGB P11216 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28991368 0.90 LMNA (0.36) LMNAALOX12ADRA1ASMN1; SMN2PYGM
SCHEMBL8744204 0.78 TK1 (0.40) LMNAADRA1ATK2TK1
SCHEMBL28639274 0.78 LMNA (0.39) LMNAALOX12ADRA1ASMN1; SMN2TK2
SCHEMBL28293098 0.78 LMNA (0.31) LMNASMN1; SMN2PYGB
SCHEMBL28252054 0.77 SLC28A1 (0.46) PYGMPYGB
SCHEMBL9216459 0.75 ALDH1A1 (0.35) LMNAADRA1ATK2TK1
SCHEMBL9226219 0.75 LMNA (0.39) LMNAALOX12ADRA1ASMN1; SMN2PYGM
SCHEMBL8987848 0.75 TK1 (0.36) LMNAADRA1ATK2TK1
SCHEMBL9229159 0.74 LMNA (0.35) LMNASMN1; SMN2
SCHEMBL9227559 0.74 LMNA (0.39) LMNAALOX12ADRA1ASMN1; SMN2TK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109641931-A Method for synthesizing ribonucleic acid H-phosphate monomer and oligonucleotide synthesis using the same 基因设计有限公司 2019-04-16 CN disclosed