Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CPT1A | P50416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828825 | 0.89 | KMT2A (0.40) | ALDH1A1NPC1KMT2AMAPTKDM4E | |
| SCHEMBL2829010 | 0.89 | HPGD (0.41) | ALDH1A1NPC1KMT2AMAPTKDM4E | |
| SCHEMBL2829418 | 0.88 | MAPT (0.40) | PTGER4ALDH1A1NPC1KMT2AMAPT | |
| SCHEMBL2825898 | 0.87 | ALDH1A1 (0.51) | PTGER4ALDH1A1NPC1KMT2AKDM4E | |
| SCHEMBL2825256 | 0.86 | ALDH1A1 (0.38) | ALDH1A1NPC1KMT2AMAPTKDM4E | |
| SCHEMBL2826438 | 0.85 | GPR52 (0.39) | TRPV1PTGER4MAPT | |
| SCHEMBL1997935 | 0.85 | SMN1; SMN2 (0.35) | TRPV1ALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL2828384 | 0.83 | SMN1; SMN2 (0.38) | TRPV1ALDH1A1NPC1KMT2AMAPT | |
| SCHEMBL2828338 | 0.83 | SMN1; SMN2 (0.41) | ALDH1A1NPC1KMT2AMAPTKDM4E | |
| SCHEMBL2828404 | 0.83 | LMNA (0.44) | TRPV1PTGER4ALDH1A1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | claimed |