Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromobenzene SCHEMBL28295090 | 0.90 | HPGD (0.45) | KMT2AMEN1POLBHPGDALDH1A1 | |
| Cadaverine Tartrate SCHEMBL28295091 | 0.86 | KLK7 (0.40) | KMT2AMEN1POLBSLC7A5ALDH1A1 | |
| Cadaverine Tartrate SCHEMBL28296886 | 0.83 | TSHR (0.46) | POLBSLC7A5L3MBTL1KDM4EHSD17B10 | |
| Cadaverine Tartrate SCHEMBL28295190 | 0.81 | LTA4H (0.44) | KMT2AMEN1HPGDALDH1A1ATM | |
| Chlorobenzene SCHEMBL27773693 | 0.76 | POLB (0.44) | KMT2AMEN1POLBALDH1A1KDM4E | |
| Biphenyl SCHEMBL3991647 | 0.76 | POLB (0.47) | KMT2AMEN1POLBHPGDALDH1A1 | |
| Chlorobenzene SCHEMBL27856994 | 0.75 | POLB (0.43) | KMT2AMEN1POLBALDH1A1KDM4E | |
| Bromobenzene SCHEMBL27324784 | 0.74 | HPGD (0.46) | KMT2AMEN1POLBHPGDALDH1A1 | |
| Toluene SCHEMBL27945492 | 0.74 | POLB (0.46) | KMT2AMEN1POLBALDH1A1L3MBTL1 | |
| Phenol SCHEMBL27480309 | 0.74 | ESRRB (0.49) | POLBHPGDALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109734617-A | A kind of method for splitting replacing aromatic ring phenylglycine aliphatic alcohol ester | 华东理工大学 | 2019-05-10 | — | — | CN | disclosed |