Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377334 | 0.91 | USP2 (0.52) | ALDH1A1NPSR1RAB9ASMN1; SMN2USP2 | |
| SCHEMBL4377384 | 0.90 | TSHR (0.53) | ALDH1A1RAB9ASMN1; SMN2USP2TSHR | |
| SCHEMBL2829573 | 0.81 | L3MBTL1 (0.48) | L3MBTL3L3MBTL1ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL14218057 | 0.78 | KMT2A (0.55) | L3MBTL1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL2852216 | 0.75 | ALDH1A1 (0.49) | L3MBTL3L3MBTL1ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL4375871 | 0.74 | RAB9A (0.55) | L3MBTL1ALDH1A1RAB9ATSHRHPGD | |
| SCHEMBL4379170 | 0.73 | MAPK1 (0.52) | ALDH1A1CYP2C19NPSR1SMN1; SMN2HPGD | |
| SCHEMBL20807374 | 0.72 | L3MBTL3 (0.53) | L3MBTL3L3MBTL1ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL2836574 | 0.71 | L3MBTL1 (0.58) | L3MBTL3L3MBTL1CYP2D6CYP2C19NPSR1 | |
| SCHEMBL4377596 | 0.71 | USP2 (0.51) | ALDH1A1SMN1; SMN2USP2TSHRUBE2N |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |