Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28051137 | 0.87 | HTT (0.61) | HTTSMN1; SMN2MAPTTP53THRB | |
| SCHEMBL28297107 | 0.85 | MAPT (0.60) | SMN1; SMN2MAPTTP53THRBLMNA | |
| SCHEMBL28298638 | 0.84 | PKM (0.45) | HTTSMN1; SMN2MAPTTP53LMNA | |
| SCHEMBL28051135 | 0.83 | HTT (0.52) | HTTSMN1; SMN2MAPTTP53THRB | |
| SCHEMBL28298639 | 0.82 | BRD1 (0.46) | HTTMAPTTP53LMNAALDH1A1 | |
| SCHEMBL28298684 | 0.81 | KMT2A (0.52) | MAPTTP53LMNAHTR6HPGD | |
| SCHEMBL28297104 | 0.81 | KMT2A (0.62) | HTTSMN1; SMN2MAPTTP53LMNA | |
| SCHEMBL6350411 | 0.79 | HTR6 (0.65) | HTTSMN1; SMN2MAPTTP53THRB | |
| SCHEMBL23148487 | 0.75 | MAPT (0.61) | HTTSMN1; SMN2MAPTTP53THRB | |
| SCHEMBL6340701 | 0.75 | SMN1; SMN2 (0.49) | HTTSMN1; SMN2MAPTTP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109851550-A | 7- aminocarbazole sulfamide derivative and its preparation method and application | 中国医学科学院医药生物技术研究所 | 2019-06-07 | — | — | CN | claimed |
| CN-109851550-A | 7- aminocarbazole sulfamide derivative and its preparation method and application | 中国医学科学院医药生物技术研究所 | 2019-06-07 | — | — | CN | disclosed |