Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28310894 | 0.82 | PABPC1 (0.36) | PABPC1KMT2AMAPTMMP1MMP13 | |
| SCHEMBL31716247 | 0.71 | KDM4E (0.39) | KDM4EKMT2ATP53SMN1; SMN2MAPT | |
| SCHEMBL17128052 | 0.71 | KDM4E (0.39) | KDM4EKMT2ATP53SMN1; SMN2MAPT | |
| SCHEMBL11701895 | 0.71 | DYRK1A (0.41) | KDM4EKMT2ATP53SMN1; SMN2MAPT | |
| SCHEMBL17598440 | 0.71 | HTT (0.42) | KDM4EKMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL22118253 | 0.70 | ALDH1A1 (0.48) | KDM4EKMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL28311761 | 0.70 | KDM4E (0.45) | KDM4EMMP1MMP13ADAM17MMP9 | |
| SCHEMBL22118247 | 0.69 | MMP1 (0.36) | KDM4EKMT2ATP53SMN1; SMN2MMP1 | |
| SCHEMBL11465590 | 0.67 | KDM4E (0.40) | KDM4EKMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL11207914 | 0.65 | TSHR (0.44) | PABPC1KDM4EMAPTMMP9HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110003171-B | Small molecule reversible BTK inhibitor for treating rheumatoid arthritis | 清华大学 | 2020-11-06 | — | — | CN | disclosed |
| CN-110003171-A | The small molecule invertibity BTK inhibitor for treating rheumatoid arthritis | 清华大学 | 2019-07-12 | — | — | CN | disclosed |