Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 1/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.55 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | WDR5 | P61964 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749671 | 0.85 | ALDH1A1 (0.44) | CYP1A1CYP1B1NCEH1MAPTALDH1A1 | |
| SCHEMBL8097610 | 0.82 | CYP1A1 (0.57) | CYP1A1CYP1B1NCEH1MAPTALDH1A1 | |
| SCHEMBL689752 | 0.82 | WDR5 (0.66) | CYP1A1CYP1B1NCEH1MAPTALDH1A1 | |
| SCHEMBL30791069 | 0.82 | WDR5 (0.66) | CYP1A1CYP1B1NCEH1MAPTALDH1A1 | |
| SCHEMBL13905710 | 0.81 | CYP1A1 (0.55) | CYP1A1CYP1B1NCEH1MAPTALDH1A1 | |
| SCHEMBL8681263 | 0.81 | CYP1A1 (0.55) | CYP1A1CYP1B1NCEH1MAPTALDH1A1 | |
| SCHEMBL2055410 | 0.80 | NCEH1 (0.58) | CYP1A1CYP1B1NCEH1WDR5LDHA | |
| SCHEMBL1287839 | 0.80 | NCEH1 (0.54) | CYP1A1CYP1B1NCEH1MAPTALDH1A1 | |
| SCHEMBL21901499 | 0.80 | CYP1A1 (0.51) | CYP1A1CYP1B1NCEH1MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL8803047 | 0.79 | NCEH1 (0.53) | CYP1A1CYP1B1NCEH1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101704758-B | Method for preparing 2-naphthylamine | UNIV BEIJING NORMAL | 2013-06-05 | — | — | CN | claimed |
| CN-101704758-A | Method for preparing 2-naphthylamine | UNIV BEIJING NORMAL | 2010-05-12 | — | — | CN | claimed |
| CN-101704758-B | Method for preparing 2-naphthylamine | UNIV BEIJING NORMAL | 2013-06-05 | — | — | CN | disclosed |
| CN-101704758-B | Method for preparing 2-naphthylamine | UNIV BEIJING NORMAL | 2013-06-05 | — | — | CN | disclosed |
| US-7781441-B2 | (3,4-dihydro-quinazolin-2-yl)-(2-aryloxy-ethyl)-amine | HOFFMANN-LA ROCHE INC. (US) | 2010-08-24 | — | — | US | disclosed |
| US-7754273-B2 | Method of printing a time-temperature indicator based on azo coupling reactions onto a susbtrate | CIBA SPECIALTY CHEMICALS CORP. (US) | 2010-07-13 | — | — | US | disclosed |
| CN-101704758-A | Method for preparing 2-naphthylamine | UNIV BEIJING NORMAL | 2010-05-12 | — | — | CN | disclosed |
| CN-101704758-A | Method for preparing 2-naphthylamine | UNIV BEIJING NORMAL | 2010-05-12 | — | — | CN | disclosed |
| EP-1888538-B1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-(2-ARYLOXY-ETHYL)-AMINES HAVING AN ACTIVITY ON THE 5-HT RECEPTOR | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | disclosed |
| EP-1888538-A1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-(2-ARYLOXY-ETHYL)-AMINES HAVING AN ACTIVITY ON THE 5-HT RECEPTOR | F. Hoffmann-Roche AG (CH) | 2008-02-20 | — | — | EP | disclosed |
| US-20070218206-A1 | Method of Printing a Time-Temperature Indicator Based on Azo Coupling Reactions onto a Susbtrate | CIBA SPECIALTY CHEMICALS CORP. | 2007-09-20 | — | — | US | disclosed |
| US-20060252779-A1 | (3,4-Dihydro-quinazolin-2-yl)-(2-aryloxy-ethyl)-amine | HOFFMANN-LA ROCHE INC. | 2006-11-09 | — | — | US | disclosed |
| WO-2006117305-A1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-(2-ARYLOXY-ETHYL)-AMINES HAVING AN ACTIVITY ON THE 5-HT RECEPTOR | F. HOFFMANN-LA ROCHE AG (CH) | 2006-11-09 | — | — | WO | disclosed |
| US-5171880-A | Sulfur or oxidized sulfur in a base | ALLIED-SIGNAL INC. (US) | 1992-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252779-A1 | (3,4-Dihydro-quinazolin-2-yl)-(2-aryloxy-ethyl)-amine | HTR5A, NPY5R, HTR3A | CYP1A1 456/4885CYP1B1 582/4885NCEH1 2241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.