Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | ACACA | Q13085 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378673 | 0.91 | KDM4E (0.62) | MEN1KMT2AKDM4EALDH1A1OPRD1 | |
| SCHEMBL4378669 | 0.90 | KDM4E (0.61) | MEN1KMT2AKDM4EALDH1A1OPRD1 | |
| SCHEMBL2836399 | 0.86 | HRH3 (0.58) | KDM4EALDH1A1L3MBTL3L3MBTL1ACHE | |
| SCHEMBL3765916 | 0.86 | KDM4E (0.53) | MEN1KMT2AKDM4EALDH1A1OPRD1 | |
| SCHEMBL14218030 | 0.78 | HSD11B1 (0.60) | MEN1KMT2AKDM4EALDH1A1OPRD1 | |
| SCHEMBL13090033 | 0.77 | OPRD1 (0.49) | MEN1KMT2AOPRD1OPRK1RIPK1 | |
| SCHEMBL4380547 | 0.77 | ALDH1A1 (0.64) | KMT2AKDM4EALDH1A1HRH3 | |
| SCHEMBL2828800 | 0.77 | ACHE (0.67) | CYP2D6CYP2C19NPSR1KDM4EALDH1A1 | |
| SCHEMBL4976765 | 0.76 | ENPP2 (0.42) | KDM4EALDH1A1RIPK1SIGMAR1 | |
| SCHEMBL4375759 | 0.76 | ALDH1A1 (0.63) | KMT2AKDM4EALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |