Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2838800 | 0.81 | NPC1 (0.42) | NPC1ALDH1A1LMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2845874 | 0.76 | KDM4E (0.34) | PGRTDP1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6642453 | 0.68 | TDP1 (0.41) | TDP1KDM4EALDH1A1HSD11B1KMT2A | |
| SCHEMBL9207748 | 0.67 | KDM4E (0.42) | KDM4EALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL14344953 | 0.66 | MAPT (0.38) | PGRTDP1KDM4EALDH1A1KMT2A | |
| SCHEMBL26986912 | 0.65 | GSK3B (0.41) | TDP1KDM4EALDH1A1HSD11B1KMT2A | |
| SCHEMBL2663390 | 0.65 | MAPT (0.48) | TDP1KDM4EALDH1A1LMNARAB9A | |
| SCHEMBL27622744 | 0.65 | SLC18A3 (0.59) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL25288553 | 0.65 | THRB (0.43) | TDP1KDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6992740 | 0.64 | SMYD3 (0.44) | TDP1KDM4EALDH1A1HSD11B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217031-B2 | Heteroaryl derivatives | NIPPON SHINYAKU CO., LTD. (JP) | 2012-07-10 | — | — | US | disclosed |
| US-20100048537-A1 | HETEROARYL DERIVATIVES | NIPPON SHINYAKU CO., LTD. (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2141168-A1 | HETEROARYL DERIVATIVES | Nippon Shinyaku Co., Ltd. (JP) | 2010-01-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048537-A1 | HETEROARYL DERIVATIVES | OPRD1, OPRM1, OPRK1 | PGR 2084/4885TDP1 3509/4885KDM4E 3292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.