SCHEMBL2835834

SCHEMBL2835834

CC(C)(C)[Si](C)(C)O[C@@H](C(=O)c1ccccc1)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C[C@@H]1O

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.45
ENPP1 P22413 2/20 0.43
P2RY1 P47900 1/20 0.43
ADORA1 P30542 2/20 0.42
AHCY P23526 6/20 0.41
P2RX3 P56373 1/20 0.41
P2RX4 Q99571 1/20 0.41
P2RX2 Q9UBL9 1/20 0.41
STING1 Q86WV6 1/20 0.41
HIF1A Q16665 1/20 0.40
TMEM97 Q5BJF2 1/20 0.40
SIGMAR1 Q99720 1/20 0.40
ADORA3 P0DMS8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL718524 1.00 POLB (0.45) POLBENPP1P2RY1ADORA1AHCY
SCHEMBL715688 0.86 P2RX3 (0.39) POLBADORA1AHCYP2RX3P2RX4
SCHEMBL5348155 0.83 CHKA (0.42) POLBENPP1P2RY1ADORA1AHCY
SCHEMBL719007 0.78 POLB (0.43) POLB
SCHEMBL888069 0.78 POLB (0.46) POLBENPP1P2RY1AHCYSTING1
SCHEMBL888256 0.77 STING1 (0.42) POLBENPP1P2RY1AHCYSTING1
SCHEMBL1901202 0.77 POLB (0.42) POLBENPP1P2RY1ADORA1AHCY
SCHEMBL5859661 0.77 P2RX3 (0.43) POLBENPP1P2RY1ADORA1AHCY
SCHEMBL2952877 0.76 POLB (0.44) POLBENPP1P2RY1ADORA1AHCY
SCHEMBL3969539 0.76 AHCY (0.49) POLBENPP1P2RY1ADORA1AHCY

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240076731-A1 METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES QIAGEN SCIENCES, LLC 2024-03-07 US disclosed
US-20240060128-A1 METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES QIAGEN WALTHAM, INC. 2024-02-22 US disclosed
US-20230407384-A1 METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES QIAGEN WALTHAM, INC. 2023-12-21 US disclosed
US-20210230686-A1 METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES IsoPlexis Corporation 2021-07-29 US disclosed
US-20210231609-A1 METHODS AND DEVICES FOR SEQUENCING NUCLEIC ACIDS IN SMALLER BATCHES IsoPlexis Corporation 2021-07-29 US disclosed
US-11035823-B2 Methods and devices for sequencing nucleic acids in smaller batches QIAGEN SCIENCES, LLC (US) 2021-06-15 US disclosed
US-11001887-B2 Methods and compositions for incorporating nucleotides QIAGEN SCIENCES, LLC (US) 2021-05-11 US disclosed
US-10745740-B2 Sample preparation QIAGEN SCIENCES, LLC (US) 2020-08-18 US disclosed
US-20200149089-A9 Sample Preparation IsoPlexis Corporation 2020-05-14 US disclosed
US-20200040391-A1 Methods and Compositions for Incorporating Nucleotides IsoPlexis Corporation 2020-02-06 US disclosed
US-8623598-B2 Methods and compositions for inhibiting undesired cleaving of labels Intelligent Bio Systems, Inc. (US) 2014-01-07 US disclosed
US-8612161-B2 Methods and compositions for base calling nucleic acids INTELLIGENT BIOSYSTEMS INC. (US) 2013-12-17 US disclosed
US-20130316914-A1 Methods And Devices For Sequencing Nucleic Acids In Smaller Batches INTELLIGENT BIOSYSTEMS, INC. 2013-11-28 US disclosed
US-20130301888-A1 Methods And Compositions For Base Calling Nucleic Acids IsoPlexis Corporation 2013-11-14 US disclosed
US-8481259-B2 Methods and devices for sequencing nucleic acids in smaller batches INTELLIGENT BIO-SYSTEMS, INC. (US) 2013-07-09 US disclosed
US-20130137091-A1 Methods And Compositions For Incorporating Nucleotides INTELLIGENT BIO-SYSTEMS, INC. 2013-05-30 US disclosed
US-20100323350-A1 Methods And Devices For Sequencing Nucleic Acids In Smaller Batches INTELLIGENT BIOSYSTEMS, INC. 2010-12-23 US disclosed
US-20100063743-A1 Methods And Compositions For Base Calling Nucleic Acids INTELLIGENT BIO-SYSTEMS, INC. 2010-03-11 US disclosed
US-20100035253-A1 Methods And Compositions For Incorporating Nucleotides INTELLIGENT BIO-SYSTEMS, INC. 2010-02-11 US disclosed
WO-2009117119-A1 METHODS AND COMPOSITIONS FOR BASE CALLING NUCLEIC ACIDS INTELLIGENT BIO-SYSTEMS, INC. (US) 2009-09-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210230686-A1 METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES NT5C2, NOP2, NT5C3B POLB 44/4885ENPP1 165/4885P2RY1 217/4885
US-20200040391-A1 Methods and Compositions for Incorporating Nucleotides NT5C2, NOP2, NT5C3B POLB 44/4885ENPP1 165/4885P2RY1 217/4885
US-20240076731-A1 METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES NT5C2, NOP2, NT5C3B POLB 44/4885ENPP1 165/4885P2RY1 217/4885
US-11001887-B2 Methods and compositions for incorporating nucleotides NT5C2, NOP2, NT5C3B POLB 44/4885ENPP1 165/4885P2RY1 217/4885
US-20230407384-A1 METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES NT5C2, NOP2, NT5C3B POLB 44/4885ENPP1 165/4885P2RY1 217/4885
US-20240060128-A1 METHODS AND COMPOSITIONS FOR INCORPORATING NUCLEOTIDES NT5C2, NOP2, NT5C3B POLB 44/4885ENPP1 165/4885P2RY1 217/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.