Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 9/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | TP53 | P04637 | 6/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28360382 | 0.90 | LMNA (0.43) | THRBMEN1KMT2AL3MBTL1LMNA | |
| SCHEMBL28586394 | 0.80 | KMO (0.34) | THRBMEN1KMT2AL3MBTL1LMNA | |
| SCHEMBL28360376 | 0.76 | MCL1 (0.49) | L3MBTL1KDM4E | |
| SCHEMBL28364142 | 0.76 | RXFP1 (0.43) | MEN1KMT2ARXFP1 | |
| SCHEMBL28360338 | 0.74 | MCL1 (0.46) | MEN1KMT2APOLB | |
| SCHEMBL20465149 | 0.70 | MAPT (0.47) | THRBMEN1KMT2AL3MBTL1LMNA | |
| SCHEMBL28701229 | 0.70 | ALDH1A1 (0.41) | THRBMEN1KMT2ALMNAMAPT | |
| SCHEMBL26745662 | 0.70 | RXFP1 (0.50) | THRBMEN1KMT2AL3MBTL1LMNA | |
| SCHEMBL28701232 | 0.69 | ACP3 (0.43) | LMNATP53TDP1 | |
| SCHEMBL30547707 | 0.67 | KDM4E (0.68) | THRBMEN1KMT2AL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110669046-A | Polysubstituted tetrahydro-gamma-carboline derivative with multiple chiral centers and preparation method of stereo diversity of polysubstituted tetrahydro-gamma-carboline derivative | 武汉大学 | 2020-01-10 | — | — | CN | disclosed |