Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28360382 | 0.85 | LMNA (0.43) | KMT2AMEN1POLB | |
| SCHEMBL28586394 | 0.85 | KMO (0.34) | AHRKMT2AMEN1 | |
| SCHEMBL28364142 | 0.84 | RXFP1 (0.43) | KMT2AMEN1PHGDH | |
| SCHEMBL28360376 | 0.84 | MCL1 (0.49) | MCL1 | |
| SCHEMBL28364144 | 0.81 | SLC9A1 (0.41) | NPC1RAB9AKMT2AMEN1SLC9A1 | |
| SCHEMBL28364015 | 0.81 | CNR2 (0.31) | KMT2AMEN1 | |
| SCHEMBL13760820 | 0.74 | MCL1 (0.47) | MCL1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL28363847 | 0.74 | THRB (0.41) | KMT2AMEN1POLB | |
| SCHEMBL13754051 | 0.74 | KMT2A (0.38) | MCL1KMT2ADAO | |
| SCHEMBL5837445 | 0.74 | KMT2A (0.47) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110669046-B | Polysubstituted tetrahydro-gamma-carboline derivative with multiple chiral centers and preparation method of stereo diversity of polysubstituted tetrahydro-gamma-carboline derivative | 武汉大学 | 2021-07-06 | — | — | CN | disclosed |
| CN-110669046-A | Polysubstituted tetrahydro-gamma-carboline derivative with multiple chiral centers and preparation method of stereo diversity of polysubstituted tetrahydro-gamma-carboline derivative | 武汉大学 | 2020-01-10 | — | — | CN | disclosed |