Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28366232 | 0.88 | KIF11 (0.45) | KIF11SMN1; SMN2G6PDTLR9SLC6A9 | |
| SCHEMBL28057350 | 0.83 | ALDH1A1 (0.49) | KEAP1NFE2L2LMNASMN1; SMN2G6PD | |
| SCHEMBL23902692 | 0.82 | LMNA (0.49) | TNFKEAP1NFE2L2KIF11LMNA | |
| SCHEMBL30241541 | 0.82 | LMNA (0.49) | TNFKEAP1NFE2L2KIF11LMNA | |
| SCHEMBL14966484 | 0.80 | KEAP1 (0.46) | KEAP1NFE2L2KIF11LMNASMN1; SMN2 | |
| Trifluoromethanesulfonic Acid SCHEMBL27781891 | 0.72 | POLB (0.38) | LMNASMN1; SMN2PHOSPHO1MAPT | |
| SCHEMBL9920084 | 0.72 | MEN1 (0.55) | HTTMAPTRXFP1 | |
| SCHEMBL807891 | 0.71 | G6PD (0.43) | KIF11LMNAG6PDTLR9ABL1 | |
| SCHEMBL439710 | 0.70 | TSHR (0.61) | KEAP1NFE2L2KIF11LMNAMAPT | |
| SCHEMBL29703748 | 0.70 | TSHR (0.61) | KEAP1NFE2L2KIF11LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105523996-B | Amide derivatives, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2020-03-06 | — | — | CN | disclosed |