Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | PRKCB | P05771 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | REN | P00797 | 2/20 | 0.30 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2835561 | 0.87 | GFER (0.31) | GPR119GFER | |
| SCHEMBL2841338 | 0.87 | SIRT2 (0.32) | SIRT2GPR119GFERPROKR1 | |
| SCHEMBL2791712 | 0.86 | ALDH1A1 (0.33) | ALDH1A1CYP3A4LMNACYP2D6CYP2C9 | |
| SCHEMBL2791715 | 0.86 | ALDH1A1 (0.33) | ALDH1A1CYP3A4LMNACYP2D6CYP2C9 | |
| SCHEMBL2835610 | 0.86 | GFER (0.31) | GPR119GFER | |
| SCHEMBL2792001 | 0.85 | TRPV3 (0.33) | ALDH1A1GPR119GFERRENPROKR1 | |
| SCHEMBL2790130 | 0.85 | ALOX5AP (0.34) | ALDH1A1CYP3A4GPR119GFERREN | |
| SCHEMBL2791546 | 0.85 | ALDH1A1 (0.36) | ALDH1A1CYP3A4NAMPTPRKCBGFER | |
| SCHEMBL2790241 | 0.85 | ALDH1A1 (0.36) | ALDH1A1CYP3A4NAMPTPRKCBGFER | |
| SCHEMBL2790403 | 0.80 | PABPC1 (0.32) | ALDH1A1CYP3A4LMNACYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |