Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31487872 | 0.84 | ALDH1A1 (0.56) | ALDH1A1MAPTKMT2ARAB9AGAA | |
| SCHEMBL265259 | 0.84 | ALDH1A1 (0.56) | ALDH1A1MAPTKMT2ARAB9AGAA | |
| Hydrochloric Acid SCHEMBL28566743 | 0.82 | MAPT (0.54) | ALDH1A1MAPTKMT2ARAB9AGAA | |
| Phenazine SCHEMBL28375190 | 0.82 | ALDH1A1 (0.56) | ALDH1A1MAPTKMT2ARAB9ANQO2 | |
| SCHEMBL23589560 | 0.78 | NQO2 (0.52) | ALDH1A1MAPTKMT2ARAB9AGAA | |
| Maleic Acid SCHEMBL123790 | 0.78 | ALDH1A1 (0.63) | ALDH1A1MAPTKMT2ARAB9AGAA | |
| SCHEMBL31558290 | 0.78 | NQO2 (0.52) | ALDH1A1MAPTKMT2ARAB9AGAA | |
| Maleic Acid SCHEMBL1155758 | 0.78 | ALDH1A1 (0.63) | ALDH1A1MAPTKMT2ARAB9AGAA | |
| SCHEMBL7568127 | 0.76 | ALDH1A1 (0.71) | ALDH1A1MAPTKMT2ARAB9ANQO2 | |
| SCHEMBL7572097 | 0.75 | ALDH1A1 (0.69) | ALDH1A1MAPTKMT2ARAB9ANQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110934833-B | Compound paracetamol and chlorphenamine maleate granules | 河北长天药业有限公司 | 2022-08-19 | — | — | CN | disclosed |