Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ACP3 | P15309 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | EEF2K | O00418 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MASP2 | O00187 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21483640 | 0.69 | P2RX3 (0.39) | KDM4EPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL143208 | 0.65 | ALDH1A1 (0.56) | KDM4EBACE1POLBALDH1A1MAPT | |
| SCHEMBL11545249 | 0.65 | ACP3 (0.46) | KDM4EACP3BACE1ALDH1A1OPRM1 | |
| SCHEMBL5797006 | 0.64 | CRBN (0.44) | POLBGAAPKMMEN1KMT2A | |
| SCHEMBL7052353 | 0.63 | L3MBTL1 (0.38) | KDM4EPOLBALDH1A1MAPTCYP1A2 | |
| SCHEMBL5658114 | 0.62 | RAB9A (0.47) | KDM4EACP3POLBALDH1A1MAPT | |
| SCHEMBL9793652 | 0.61 | ALDH1A1 (0.38) | KDM4EACP3ALDH1A1MAPTCYP2D6 | |
| SCHEMBL8481152 | 0.61 | POLB (0.67) | KDM4EPOLBALDH1A1MAPTCYP1A2 | |
| SCHEMBL19892577 | 0.60 | ALDH1A1 (0.39) | KDM4EPOLBALDH1A1MAPTCYP1A2 | |
| SCHEMBL7052356 | 0.59 | GSK3A (0.40) | KDM4EBACE1POLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107652228-B | Synthesis method of anti-renal fibrosis drug 1- (substituted benzyl) -5-trifluoromethyl-2 (1H) -pyridone hydrochloride | 广州南新制药有限公司 | 2020-04-14 | — | — | CN | disclosed |