SCHEMBL28378015

SCHEMBL28378015

O=C(OCc1ccccc1)N(c1cc(NC(=O)C(F)(F)F)n[nH]1)C1CCCCC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ENPP2 Q13822 1/20 0.46
USP30 Q70CQ3 1/20 0.41
CDK2 P24941 3/20 0.37
CCNA2 P20248 2/20 0.37
ALDH1A1 P00352 1/20 0.37
CCNA1 P78396 1/20 0.37
PTGDR2 Q9Y5Y4 2/20 0.37
EPHX1 P07099 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
CCNE1 P24864 1/20 0.36
CDK9 P50750 1/20 0.36
CDK5 Q00535 1/20 0.36
CDK5R1 Q15078 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
CHRM2 P08172 1/20 0.36
CHRM5 P08912 1/20 0.36
CHRM1 P11229 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28377263 0.82 CDK2 (0.35) CDK2CCNA2CCNA1CCNE1CDK9
SCHEMBL28383572 0.80 ENPP2 (0.53) ENPP2ALDH1A1EPHX1MEN1KMT2A
SCHEMBL28381709 0.76 FGFR4 (0.46) ENPP2USP30CDK2CCNA2ALDH1A1
SCHEMBL28378009 0.76 AGER (0.42) CDK2CCNA2CCNA1PTGDR2CCNE1
SCHEMBL28378012 0.73 USP30 (0.46) USP30CDK2CCNA2ALDH1A1CCNA1
SCHEMBL22356643 0.69 NPY5R (0.41) ENPP2ALDH1A1MEN1KMT2AFLT1
SCHEMBL21872794 0.68 ENPP2 (0.60) ENPP2ALDH1A1EPHX1MEN1KMT2A
SCHEMBL29009687 0.67 ENPP2 (0.58) ENPP2ALDH1A1EPHX1MEN1KMT2A
SCHEMBL7110222 0.66 ENPP2 (0.64) ENPP2ALDH1A1MEN1KMT2ACHRM2
SCHEMBL4056164 0.66 ENPP2 (0.54) ENPP2ALDH1A1EPHX1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110997637-A Aromatic derivative, preparation method and application thereof in medicine 博奥阿迪斯生物科技公司 2020-04-10 CN disclosed