Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28191858 | 0.85 | MKNK1 (0.39) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL2393997 | 0.83 | TRIM24 (0.50) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL754122 | 0.83 | KDM4E (0.55) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL16239166 | 0.81 | KDM4E (0.40) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL7222788 | 0.81 | KDM4E (0.40) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL31628026 | 0.81 | ALDH1A1 (0.41) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL16239168 | 0.81 | KDM4E (0.53) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL1515655 | 0.79 | MKNK1 (0.38) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL13388358 | 0.77 | MAPT (0.37) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL13379447 | 0.77 | MAPK1 (0.39) | KDM4EMAPTALDH1A1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12152013-B2 | Vinylpyridine carboxamide compound as PD-L1 immunomodulator | NOVAONCO JS THERAPEUTICS CO., LTD. (CN) | 2024-11-26 | — | — | US | disclosed |
| CN-115989224-A | Plasma kallikrein inhibitors | 默沙东有限责任公司 | 2023-04-18 | — | — | CN | disclosed |
| US-20230077268-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. | 2023-03-09 | — | — | US | disclosed |
| CN-113439080-B | Vinylpyridine carboxamides as PD-L1 immunomodulators | 上海复星医药产业发展有限公司 | 2022-12-20 | — | — | CN | disclosed |
| CN-113439080-B | Vinylpyridine carboxamides as PD-L1 immunomodulators | 上海复星医药产业发展有限公司 | 2022-12-20 | — | — | CN | disclosed |
| EP-3919478-A4 | VINYLPYRIDINE CARBOXAMIDE COMPOUND AS PD-L1 IMMUNOMODULATOR | Shanghai Fosun Pharmaceutical Industrial Development Co., Ltd. (CN) | 2022-12-07 | — | — | EP | disclosed |
| US-11427558-B1 | Indazoles and azaindazoles as LRRK2 inhibitors | ESCAPE Bio, Inc. (US) | 2022-08-30 | — | — | US | disclosed |
| US-20220144806-A1 | VINYLPYRIDINE CARBOXAMIDE COMPOUND AS PD-L1 IMMUNOMODULATOR | ShanghaiFosunPharmaceuticalIndustrialDevelopmentCo., (CN) | 2022-05-12 | — | — | US | disclosed |
| CN-113439080-A | Vinylpyridine carboxamides as PD-L1 immunomodulators | 南京明德新药研发有限公司 | 2021-09-24 | — | — | CN | disclosed |
| CN-113439080-A | Vinylpyridine carboxamides as PD-L1 immunomodulators | 南京明德新药研发有限公司 | 2021-09-24 | — | — | CN | disclosed |
| EP-2091936-B1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | PURDUE PHARMA LP (US) | 2013-05-15 | — | — | EP | disclosed |
| US-8389549-B2 | Substituted pyridines useful for treating pain | PURDUE PHARMA L.P. (US) | 2013-03-05 | — | — | US | disclosed |
| EP-2479173-A1 | Therapeutic agents useful for treating pain | Purdue Pharma LP (US) | 2012-07-25 | — | — | EP | disclosed |
| US-20100130552-A1 | Therapeutic Agents Useful for Treating Pain | PURDUE PHARMA L.P. | 2010-05-27 | — | — | US | disclosed |
| EP-2091936-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | Purdue Pharma LP (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008133973-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | PURDUE PHARMA L.P. (DE) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144806-A1 | VINYLPYRIDINE CARBOXAMIDE COMPOUND AS PD-L1 IMMUNOMODULATOR | PDCD1, CD274, PDCD1LG2 | KDM4E 110/4885MAPT 2887/4885ALDH1A1 135/4885 |
| US-11427558-B1 | Indazoles and azaindazoles as LRRK2 inhibitors | LRRK2, PARK7, GDI2 | KDM4E 1401/4885MAPT 66/4885ALDH1A1 1904/4885 |
| US-20100130552-A1 | Therapeutic Agents Useful for Treating Pain | ARRB1, OPRK1, OPRD1 | KDM4E 4611/4885MAPT 2790/4885ALDH1A1 587/4885 |
| US-20230077268-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | LRRK2, PARK7, GDI2 | KDM4E 1401/4885MAPT 66/4885ALDH1A1 1904/4885 |
| US-12152013-B2 | Vinylpyridine carboxamide compound as PD-L1 immunomodulator | PDCD1, CD274, PDCD1LG2 | KDM4E 110/4885MAPT 2887/4885ALDH1A1 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.