Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.83 |
| ▸ | LMNA | P02545 | 1/20 | 0.83 |
| ▸ | PGR | P06401 | 1/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | FNTA | P49354 | 1/20 | 0.47 |
| ▸ | FNTB | P49356 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.39 |
| ▸ | SQLE | Q14534 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2837986 | 1.00 | NR1I2 (0.83) | NR1I2LMNAPGRALDH1A1FNTA | |
| SCHEMBL16431721 | 1.00 | NR1I2 (0.83) | NR1I2LMNAPGRALDH1A1FNTA | |
| SCHEMBL2840626 | 1.00 | NR1I2 (0.83) | NR1I2LMNAPGRALDH1A1FNTA | |
| SCHEMBL13903805 | 1.00 | NR1I2 (0.83) | NR1I2LMNAPGRALDH1A1FNTA | |
| SCHEMBL30255525 | 0.95 | NR1I2 (0.81) | NR1I2LMNAPGRALDH1A1FNTA | |
| SCHEMBL12198282 | 0.95 | NR1I2 (0.81) | NR1I2LMNAPGRALDH1A1FNTA | |
| Lycopene SCHEMBL4538742 | 0.91 | NR1I2 (1.00) | NR1I2LMNAPGRALDH1A1FNTA | |
| Lycopene SCHEMBL38650730 | 0.91 | NR1I2 (1.00) | NR1I2LMNAPGRALDH1A1FNTA | |
| SCHEMBL2833787 | 0.91 | NR1I2 (1.00) | NR1I2LMNAPGRALDH1A1FNTA | |
| Lycopene SCHEMBL21485499 | 0.91 | NR1I2 (1.00) | NR1I2LMNAPGRALDH1A1FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866323-B1 | GLUCURONIDATED NEBIVOLOL | MYLAN LAB INC (US) | 2017-05-31 | — | — | EP | disclosed |
| EP-1848424-B1 | PHARMACEUTICAL COMPOSITION COMPRISING HYDROXYLATED NEBIVOLOL | MYLAN LAB INC (US) | 2017-04-05 | — | — | EP | disclosed |
| CN-105622376-A | Method for preparing 8'-Apo-psi-caroten-8'-al | GUANGZHOU JUYUAN BIO-CHEM CO LTD | 2016-06-01 | — | — | CN | disclosed |
| CN-105622376-A | Method for preparing 8'-Apo-psi-caroten-8'-al | GUANGZHOU JUYUAN BIO-CHEM CO LTD | 2016-06-01 | — | — | CN | disclosed |
| EP-2808015-A1 | Compositions comprising nebivolol | MYLAN LABORATORIES, INC (US) | 2014-12-03 | — | — | EP | disclosed |
| US-8871748-B2 | Retinal cyclodextrin acetals and hemiacetals for treating skin complexion disorder | ISLAND KINETICS INC. (US) | 2014-10-28 | — | — | US | disclosed |
| US-8569269-B1 | Chirally correct retinal cyclodextrin hemiacetals for treating skin disorder | ISLAND KINETICS, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20130172291-A1 | RETINAL CYCLODEXTRIN ACETALS AND HEMIACETALS FOR TREATING SKIN COMPLEXION DISORDER | ISLAND KINETICS INC. (US) | 2013-07-04 | — | — | US | disclosed |
| US-8410079-B2 | Chirally correct retinal cyclodextrin hemiacetals for clarifying skin complexion | ISLAND KINETICS (US) | 2013-04-02 | — | — | US | disclosed |
| WO-2013036286-A2 | RETINAL CYCLODEXTRIN ACETALS AND HEMIACETALS FOR CLARIFYING SKIN COMPLEXION | ISLAND KINETICS INC. (US) | 2013-03-14 | — | — | WO | disclosed |
| US-20090069417-A1 | CAROTENOID OXIDATION PRODUCTS AS CHEMOPREVENTIVE AND CHEMOTHERAPEUTIC AGENTS | LY CORED LTD. (IL) | 2009-03-12 | — | — | US | disclosed |
| EP-1982711-A1 | Compositions comprsing nebivolol | MYLAN LABORATORIES, INC (US) | 2008-10-22 | — | — | EP | disclosed |
| US-20080161296-A1 | Compositions comprising nebivolol | DEY, INC. (F/K/A DEY LABORATORIES, INC.) | 2008-07-03 | — | — | US | disclosed |
| EP-1866323-A2 | GLUCURONIDATED NEBIVOLOL | MYLAN LABORATORIES, INC (US) | 2007-12-19 | — | — | EP | disclosed |
| EP-1848424-A2 | PHARMACEUTICAL COMPOSITION COMPRISING HYDROXYLATED NEBIVOLOL | MYLAN LABORATORIES, INC (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2007043046-A2 | CAROTENOID OXIDATION PRODUCTS AS CHEMOPREVENTIVE AND CHEMOTHERAPEUTIC AGENTS | LYCORED LTD. (IL) | 2007-04-19 | — | — | WO | disclosed |
| US-20070014734-A1 | Glucuronidated nebivolol metabolites | MYLAN INC. (F/K/A MYLAN LABORATORIES INC.) | 2007-01-18 | — | — | US | disclosed |
| US-20070014733-A1 | Hydroxylated nebivolol metabolites | DEY PHARMA, L.P. (F/K/A DEY L.P.) | 2007-01-18 | — | — | US | disclosed |
| WO-2006083779-A2 | PHARMACEUTICAL COMPOSITION COMPRISING HYDROXYLATED NEBIVOLOL | MYLAN LABORATORIES, INC. (US) | 2006-08-10 | — | — | WO | disclosed |
| WO-2006083780-A2 | GLUCURONIDATED NEBIVOLOL | MYLAN LABORATORIES, INC. (US) | 2006-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161296-A1 | Compositions comprising nebivolol | ADRB1, ADRB3, ADRB2 | NR1I2 554/4885LMNA 185/4885PGR 3963/4885 |
| US-20130172291-A1 | RETINAL CYCLODEXTRIN ACETALS AND HEMIACETALS FOR TREATING SKIN COMPLEXION DISORDER | CRYAA, HCCS, COL14A1 | NR1I2 524/4885LMNA 1235/4885PGR 2590/4885 |
| US-20070014734-A1 | Glucuronidated nebivolol metabolites | UGT1A4, UGT1A3, UGT1A1 | NR1I2 241/4885LMNA 1082/4885PGR 3024/4885 |
| US-20090069417-A1 | CAROTENOID OXIDATION PRODUCTS AS CHEMOPREVENTIVE AND CHEMOTHERAPEUTIC AGENTS | DOHH, BBOX1, TXN2 | NR1I2 1186/4885LMNA 548/4885PGR 2394/4885 |
| US-20070014733-A1 | Hydroxylated nebivolol metabolites | EDNRB, EDNRA, ADRB1 | NR1I2 967/4885LMNA 862/4885PGR 4054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.