Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Thiobenzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 5/20 | 0.55 |
| ▸ | CES2 | O00748 | 5/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | DAO | P14920 | 1/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA4 | P22748 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiobenzoic Acid SCHEMBL26983522 | 0.94 | CES1 (0.55) | CES1CES2TSHRALDH1A1DAO | |
| Thiobenzoic Acid SCHEMBL6768672 | 0.94 | CES1 (0.55) | CES1CES2TSHRALDH1A1DAO | |
| Thiobenzoic Acid SCHEMBL11322369 | 0.94 | CES1 (0.55) | CES1CES2TSHRALDH1A1DAO | |
| Thiobenzoic Acid SCHEMBL10405316 | 0.94 | CES1 (0.55) | CES1CES2TSHRALDH1A1DAO | |
| Thiobenzoic Acid SCHEMBL6890936 | 0.94 | CES1 (0.55) | CES1CES2TSHRALDH1A1DAO | |
| Thiobenzoic Acid SCHEMBL7898028 | 0.94 | CES1 (0.55) | CES1CES2TSHRALDH1A1DAO | |
| Thiobenzoic Acid SCHEMBL2165570 | 0.94 | CES1 (0.55) | CES1CES2TSHRALDH1A1DAO | |
| Thiobenzoic Acid SCHEMBL20741483 | 0.94 | CES1 (0.55) | CES1CES2TSHRALDH1A1DAO | |
| Thiobenzoic Acid SCHEMBL22721210 | 0.94 | CES1 (0.55) | CES1CES2TSHRALDH1A1DAO | |
| Thiobenzoic Acid SCHEMBL3343877 | 0.94 | CES1 (0.55) | CES1CES2TSHRALDH1A1DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118894800-A | Preparation method of Lefamulin intermediate compound | 福建省微生物研究所 | 2024-11-05 | — | — | CN | claimed |
| CN-118496133-A | Method for synthesizing thioamide compound by using aryl chloride and isonitrile | 华南理工大学 | 2024-08-16 | — | — | CN | claimed |
| CN-114805384-A | Method for preparing D-biotin intermediate | 帝斯曼知识产权资产管理有限公司 | 2022-07-29 | — | — | CN | claimed |
| US-7122693-B2 | Acetaldehyde acetal compounds, their synthesis, and uses thereof | SHIRE BIOCHEM INC. (CA) | 2006-10-17 | — | — | US | claimed |
| EP-1144470-B1 | THERMALLY STABLE POLYETHERAMINES | DOW GLOBAL TECHNOLOGIES INC (US) | 2005-11-30 | — | — | EP | claimed |
| JP-62230797-A | — | — | None | — | — | JP | disclosed |
| CN-116917271-B | Process for producing arylthiol ester compound | ＡＧＣ株式会社 | 2026-05-15 | — | — | CN | disclosed |
| EP-4496795-B1 | PIPERAZINE SUBSTITUTED INDAZOLE COMPOUNDS AS INHIBITORS OF PARG | IDEAYA BIOSCIENCES INC (US) | 2026-04-01 | — | — | EP | disclosed |
| EP-4687894-A1 | COMBINATION THERAPY COMPRISING A PARG INHIBITOR AND A TOPOISOMERASE INHIBITOR FOR TREATING CANCER | Ideaya Biosciences, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| US-20250376467-A1 | PIPERAZINE SUBSTITUTED INDAZOLE COMPOUNDS AS INHIBITORS OF PARG | IDEAYA BIOSCIENCES INC (US) | 2025-12-11 | — | — | US | disclosed |
| EP-4646208-A1 | TREATMENT OF ER+ BREAST CANCER COMPRISING HOMOLOGOUS RECOMBINATION DEFICIENCY USING PARG INHIBITOR | Ideaya Biosciences, Inc. (US) | 2025-11-12 | — | — | EP | disclosed |
| CN-116531381-B | Sulfur-containing compound and pharmaceutical composition thereof | 上海日馨医药科技股份有限公司 | 2025-04-22 | — | — | CN | disclosed |
| US-4233310-A | Antiarteriosclerotic N-(mercaptoacyl)-histidines | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1980-11-11 | — | — | US | disclosed |
| US-4217352-A | ANTIARTHRITIC AGENT | MERCK & CO., INC. (US) | 1980-08-12 | — | — | US | disclosed |
| US-4208531-A | ANTIBIOTICS | CANAS RODRIQUEZ ANTONIO (GB) | 1980-06-17 | — | — | US | disclosed |
| US-4144342-A | ANTIARTHRITIC AND ANTIINFLAMMATORY AGENTS | MERCK & CO., INC. (US) | 1979-03-13 | — | — | US | disclosed |
| US-4119717-A | STEROIDS, ANTIMICROBIAL AGENTS | LEO PHARMACEUTICAL PRODUCTS LTD. A/S LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB (DK) | 1978-10-10 | — | — | US | disclosed |
| US-4061759-A | ANTIINFLAMMATORY, ARTHRITIS | MERCK & CO., INC. (US) | 1977-12-06 | — | — | US | disclosed |
| US-4053606-A | ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS | MERCK & CO., INC. (US) | 1977-10-11 | — | — | US | disclosed |
| US-4041015-A | LINEAR METAL POLYSULFIDES | M&T CHEMICALS INC. (US) | 1977-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250376467-A1 | PIPERAZINE SUBSTITUTED INDAZOLE COMPOUNDS AS INHIBITORS OF PARG | PARG, PARP15, PARP11 | CES1 2626/4885CES2 1302/4885TSHR 4341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.