Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28396386 | 0.86 | MAPT (0.40) | MAPTHTTDHODHL3MBTL1ALDH1A1 | |
| SCHEMBL28259961 | 0.85 | MEN1 (0.47) | HTTL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL28279915 | 0.84 | MEN1 (0.49) | HTTL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL28391966 | 0.81 | SMN1; SMN2 (0.39) | MAPTHTTALDH1A1RAB9AMEN1 | |
| SCHEMBL27972568 | 0.78 | MEN1 (0.53) | MAPTHTTL3MBTL1ALDH1A1RAB9A | |
| SCHEMBL28392159 | 0.75 | RAB9A (0.41) | MAPTHTTALDH1A1RAB9ANPC1 | |
| SCHEMBL28261357 | 0.75 | KDR (0.34) | MAPTALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL28420648 | 0.73 | ALDH1A1 (0.45) | MAPTDHODHALDH1A1RAB9AMEN1 | |
| SCHEMBL28426457 | 0.72 | CHRNB2 (0.43) | L3MBTL1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27972549 | 0.72 | SMO (0.53) | MAPTL3MBTL1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108863959-B | P2X4 receptor antagonists | 日本化学药品株式会社 | 2021-11-30 | — | — | CN | disclosed |
| CN-111333588-A | P2X4 receptor antagonists | 日本化学药品株式会社 | 2020-06-26 | — | — | CN | disclosed |