Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3418973 | 0.76 | ALDH1A1 (0.51) | MAPTHDAC1HDAC8HDAC6HDAC3 | |
| Pyrazine Carboxylic Acid Hydrazide SCHEMBL107341 | 0.72 | ADORA3 (0.61) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL14119711 | 0.72 | CYP1A2 (0.44) | MAPTKMT2AMEN1POLBBLM | |
| SCHEMBL13815661 | 0.72 | HSP90AA1 (0.43) | MAPTKMT2AMEN1SMN1; SMN2PIM1 | |
| SCHEMBL1343655 | 0.72 | PIM1 (0.47) | POLBPIM1PIM2CYP1A2NPSR1 | |
| Pyrazine Carboxylic Acid Hydrazide SCHEMBL18038330 | 0.71 | ADORA3 (0.59) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL20507844 | 0.71 | WNT3A (0.56) | SMN1; SMN2 | |
| SCHEMBL2553430 | 0.69 | HDAC6 (0.77) | HDAC1HDAC8HDAC6HDAC2PIM1 | |
| SCHEMBL27873381 | 0.67 | KDM4E (0.53) | MAPTHDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL23950158 | 0.66 | ALOX15 (0.51) | MAPTHDAC1HDAC8HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107382977-B | Pyrazinepyrazole acylhydrazone derivative-based fluorescent probe and preparation method and application thereof | 河南理工大学 | 2020-07-28 | — | — | CN | claimed |
| CN-107382977-B | Pyrazinepyrazole acylhydrazone derivative-based fluorescent probe and preparation method and application thereof | 河南理工大学 | 2020-07-28 | — | — | CN | disclosed |