Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TCF4 | P15884 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28432202 | 0.88 | MAPT (0.54) | SMN1; SMN2LMNAHPGDALDH1A1LIMK2 | |
| SCHEMBL28428561 | 0.83 | CCR8 (0.55) | LMNAHPGDALDH1A1LIMK2MEN1 | |
| SCHEMBL28428653 | 0.82 | MAPT (0.50) | SMN1; SMN2ALDH1A1LIMK2MAPK1HTT | |
| SCHEMBL28438687 | 0.74 | GAA (0.55) | LMNAALDH1A1HTTMAPTMEN1 | |
| SCHEMBL14403263 | 0.73 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAALDH1A1MAPK1HTT | |
| SCHEMBL28437276 | 0.72 | IDH1 (0.54) | SMN1; SMN2HPGDALDH1A1HDAC3HDAC4 | |
| SCHEMBL28436226 | 0.70 | ALDH1A1 (0.49) | ALDH1A1MAPK1MAPTMEN1KMT2A | |
| SCHEMBL28895993 | 0.68 | POLB (0.52) | ALDH1A1HTTMAPTMEN1KMT2A | |
| SCHEMBL28432982 | 0.68 | ACLY (0.50) | SMN1; SMN2ALDH1A1KDM4ELIMK2MAPK1 | |
| SCHEMBL7083981 | 0.68 | MMP1 (0.48) | SMN1; SMN2LMNAHPGDMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111056978-B | Sulfonamide compound and preparation method and application thereof | 西安交通大学 | 2021-01-19 | — | — | CN | disclosed |
| CN-111056978-A | Sulfonamide compound and preparation method and application thereof | 西安交通大学 | 2020-04-24 | — | — | CN | disclosed |