Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 19/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 16/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 16/20 | 0.70 |
| ▸ | OPRD1 | P41143 | 14/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL304322 | 0.85 | OPRL1 (0.72) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL2778830 | 0.85 | OPRL1 (0.72) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL8112806 | 0.85 | OPRM1 (0.51) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL4529459 | 0.82 | ADRA1D (0.54) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL2846505 | 0.79 | GAA (0.68) | — | |
| SCHEMBL4533417 | 0.77 | ALDH1A1 (0.66) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL2843906 | 0.77 | ALDH1A1 (0.65) | — | |
| SCHEMBL15893381 | 0.76 | OPRL1 (0.64) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL541284 | 0.76 | OPRL1 (0.75) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL304093 | 0.76 | OPRL1 (0.75) | OPRL1OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096565-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2015-08-04 | — | — | US | disclosed |
| US-9096565-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2015-08-04 | — | — | US | disclosed |
| US-9096565-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2015-08-04 | — | — | US | disclosed |
| CN-101679220-A | Histone deacetylase inhibitor | METHYLGENE INC | 2010-03-24 | — | — | CN | disclosed |
| EP-2139850-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2010-01-06 | — | — | EP | disclosed |
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2009-07-16 | — | — | US | disclosed |
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2009-07-16 | — | — | US | disclosed |
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2009-07-16 | — | — | US | disclosed |
| WO-2008122115-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2008-10-16 | — | — | WO | disclosed |
| WO-2008122115-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2008-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC11, HDAC3 | OPRL1 3314/4885OPRM1 669/4885OPRK1 2041/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.