Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | INPPL1 | O15357 | 2/20 | 0.45 |
| ▸ | INPP5A | Q14642 | 2/20 | 0.45 |
| ▸ | INPP5B | P32019 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL5669990 | 0.88 | INPPL1 (0.43) | MAPTINPPL1INPP5AINPP5BALDH1A1 | |
| Tromethamine SCHEMBL21612695 | 0.87 | INPPL1 (0.44) | MAPTINPPL1INPP5AINPP5BSRC | |
| SCHEMBL759513 | 0.86 | MAPT (0.67) | MAPTINPPL1INPP5AINPP5BLMNA | |
| SCHEMBL29429257 | 0.86 | MAPT (0.67) | MAPTINPPL1INPP5AINPP5BLMNA | |
| Ethylenediamine SCHEMBL29045380 | 0.84 | MAPT (0.62) | MAPTINPPL1INPP5AINPP5BRAB9A | |
| Phosphoric Acid SCHEMBL27473336 | 0.84 | MAPT (0.65) | MAPTINPPL1INPP5AINPP5BLMNA | |
| Tromethamine SCHEMBL7255885 | 0.83 | INPPL1 (0.44) | MAPTINPPL1INPP5AINPP5BLMNA | |
| SCHEMBL27337431 | 0.80 | MAPT (0.59) | MAPTINPPL1INPP5AINPP5BLMNA | |
| Toluene SCHEMBL28433587 | 0.78 | MAPT (0.57) | MAPTINPPL1INPP5AINPP5BLMNA | |
| Biphenyl SCHEMBL28539342 | 0.78 | MAPT (0.57) | MAPTINPPL1INPP5AINPP5BRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118073770-A | Preparation method of composite isolating film | 山东宏图新材料科技股份有限公司 | 2024-05-24 | — | — | CN | claimed |
| CN-119285670-A | Method for improving degradation resistance of phosphate fire-resistant oil | 西安热工研究院有限公司 | 2025-01-10 | — | — | CN | disclosed |
| EP-4166608-A1 | RUBBER COMPOSITION WITH LOW ODOR EMISSIONS AND PROCESS FOR ITS PRODUCTION | A.G.R. S.r.l. (IT) | 2023-04-19 | — | — | EP | disclosed |
| CN-114026179-A | Transparent polyimide film and method for producing same | 株式会社钟化 | 2022-02-08 | — | — | CN | disclosed |
| CN-112724656-A | Halogen-free flame-retardant TPU cable material and preparation method and application thereof | 福建汇得新材料有限公司 | 2021-04-30 | — | — | CN | disclosed |
| CN-106687556-B | Refrigerant mixtures comprising tetrafluoropropene, difluoromethane, pentafluoroethane and tetrafluoroethane and uses thereof | 科慕埃弗西有限公司 | 2020-10-20 | — | — | CN | disclosed |
| CN-105906929-B | Thermoplastic elastomer composition | 住友化学株式会社 | 2020-07-17 | — | — | CN | disclosed |
| US-7071347-B2 | Benzofuranone stabilization of phosphate esters | SUPRESTA LLC (US) | 2006-07-04 | — | — | US | disclosed |
| US-20060063947-A1 | BENZOFURANONE STABILIZATION OF PHOSPHATE ESTERS | ICL-IP AMERICA INC. | 2006-03-23 | — | — | US | disclosed |
| EP-1259518-B1 | BENZOFURANONE STABILIZATION OF PHOSPHATE ESTERS | AKZO NOBEL NV (NL) | 2004-06-23 | — | — | EP | disclosed |
| EP-1259518-A1 | BENZOFURANONE STABILIZATION OF PHOSPHATE ESTERS | Akzo Nobel N.V. (NL) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001066552-A1 | BENZOFURANONE STABILIZATION OF PHOSPHATE ESTERS | AKZO NOBEL N.V. (NL) | 2001-09-13 | — | — | WO | disclosed |
| CN-1114662-A | Stabilized flexible PVC | CIBA GEIGY AG (CH) | 1996-01-10 | — | — | CN | disclosed |
| US-3931360-A | ALKALI METAL NITRILOTRIACETATE | STAUFFER CHEMICAL COMPANY (US) | 1976-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063947-A1 | BENZOFURANONE STABILIZATION OF PHOSPHATE ESTERS | BPGM, DBF4, PFKFB4 | MAPT 3549/4885INPPL1 533/4885INPP5A 388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.