Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.36 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6029056 | 0.78 | SMN1; SMN2 (0.38) | EGLN2KCNMA1KDM4EALDH1A1GAA | |
| SCHEMBL7894809 | 0.78 | KCNMA1 (0.38) | KCNMA1KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL3081675 | 0.75 | BCL6 (0.37) | EGLN2KCNMA1KDM4EALDH1A1GAA | |
| SCHEMBL31437529 | 0.75 | KCNMA1 (0.36) | KCNMA1KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL6569026 | 0.75 | ALDH1A1 (0.41) | KCNMA1KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL15741203 | 0.75 | LRRK2 (0.40) | KCNMA1KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL19745473 | 0.72 | EGLN2 (0.40) | EGLN2MEN1KMT2ATRPV4ESR1 | |
| SCHEMBL5178519 | 0.72 | — | — | |
| SCHEMBL1972185 | 0.71 | EGLN2 (0.34) | EGLN2KDM4EALDH1A1GAAMEN1 | |
| SCHEMBL27916328 | 0.71 | TRPV4 (0.34) | KDM4EALDH1A1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111747952-A | Imidazoquinolinones and their use as ATM kinase inhibitors | 默克专利股份公司 | 2020-10-09 | — | — | CN | claimed |
| CN-111689963-A | Imidazoquinolinones and their use as ATM kinase inhibitors | 默克专利股份公司 | 2020-09-22 | — | — | CN | claimed |
| CN-111747952-A | Imidazoquinolinones and their use as ATM kinase inhibitors | 默克专利股份公司 | 2020-10-09 | — | — | CN | disclosed |
| CN-111689963-A | Imidazoquinolinones and their use as ATM kinase inhibitors | 默克专利股份公司 | 2020-09-22 | — | — | CN | disclosed |
| CN-107889488-B | Imidazoquinolinones and their use as ATM kinase inhibitors | 默克专利股份公司 | 2020-08-11 | — | — | CN | disclosed |