SCHEMBL6569026

SCHEMBL6569026

Cc1ccnc(O)c1C#N

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.41
LMNA P02545 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
NPC1 O15118 1/20 0.41
POLB P06746 1/20 0.41
HPGD P15428 1/20 0.41
RECQL P46063 1/20 0.41
RAB9A P51151 1/20 0.41
GAA P10253 2/20 0.36
KCNMA1 Q12791 1/20 0.36
CCR1 P32246 1/20 0.35
CCR5 P51681 1/20 0.35
CCR8 P51685 1/20 0.35
UPP1 Q16831 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C19 P33261 1/20 0.35
NOS3 P29474 2/20 0.34
NOS2 P35228 2/20 0.34
KDM4E B2RXH2 2/20 0.34
MEN1 O00255 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3559919 0.78 ALDH1A1 (0.40) ALDH1A1LMNASMN1; SMN2NPC1POLB
SCHEMBL7894809 0.78 KCNMA1 (0.38) ALDH1A1LMNASMN1; SMN2HPGDGAA
SCHEMBL30751791 0.78 ALDH1A1 (0.40) ALDH1A1LMNASMN1; SMN2NPC1POLB
SCHEMBL15691383 0.77 ALDH1A1 (0.39) ALDH1A1LMNASMN1; SMN2NPC1POLB
SCHEMBL1721807 0.75 PSMD14 (0.40) ALDH1A1LMNASMN1; SMN2NPC1POLB
SCHEMBL677194 0.75 L3MBTL1 (0.45) ALDH1A1LMNASMN1; SMN2NPC1POLB
SCHEMBL1261198 0.75 NOS2 (0.54) ALDH1A1LMNASMN1; SMN2NPC1POLB
SCHEMBL3828718 0.75 ALDH1A1 (0.44) ALDH1A1LMNASMN1; SMN2NPC1POLB
SCHEMBL16539264 0.75 ALDH1A1 (0.38) ALDH1A1LMNASMN1; SMN2NPC1POLB
SCHEMBL27158634 0.75 SMN1; SMN2 (0.40) ALDH1A1LMNASMN1; SMN2NPC1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1064265-B8 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMA (US) 2004-10-13 EP claimed
EP-1064265-B1 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMA (US) 2004-04-14 EP claimed
EP-1064265-A4 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMA (US) 2003-02-12 EP claimed
EP-1064265-A1 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 2001-01-03 EP claimed
US-6111112-A Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2000-08-29 US claimed
WO-2000043365-A1 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2000-07-27 WO claimed
US-12479827-B2 Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2025-11-25 US disclosed
CN-116120287-B Heteroaromatic carboxamide derivatives as inhibitors of plasma kallikrein 勃林格殷格翰国际有限公司 2025-01-28 CN disclosed
US-20240076286-A1 HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS BOEHRINGER INGELHEIM INT (DE) 2024-03-07 US disclosed
US-20240002363-A1 HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS BOEHRINGER INGELHEIM INT (DE) 2024-01-04 US disclosed
US-11760745-B2 Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2023-09-19 US disclosed
US-11760745-B2 Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2023-09-19 US disclosed
US-11760745-B2 Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2023-09-19 US disclosed
EP-1064265-B8 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMA (US) 2004-10-13 EP disclosed
EP-1064265-B1 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMA (US) 2004-04-14 EP disclosed
EP-1064265-A4 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMA (US) 2003-02-12 EP disclosed
EP-1064265-A1 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 2001-01-03 EP disclosed
US-6111112-A Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2000-08-29 US disclosed
WO-2000043365-A1 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2000-07-27 WO disclosed
EP-0017768-A1 Reactive dyestuffs and their use BASF Aktiengesellschaft (DE) 1980-10-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12479827-B2 Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors KLKB1, KLK5, KLK1 ALDH1A1 1223/4885LMNA 2081/4885SMN1; SMN2 4693/4885
US-11760745-B2 Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors KLKB1, KLK5, KLK1 ALDH1A1 1223/4885LMNA 2081/4885SMN1; SMN2 4693/4885
US-20240002363-A1 HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS KLKB1, KLK5, KLK1 ALDH1A1 1223/4885LMNA 2081/4885SMN1; SMN2 4693/4885
US-20240076286-A1 HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS KLKB1, KLK5, KLK1 ALDH1A1 1223/4885LMNA 2081/4885SMN1; SMN2 4693/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.