Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.77 |
| ▸ | MAPT | P10636 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | CA1 | P00915 | 2/20 | 0.77 |
| ▸ | CA2 | P00918 | 2/20 | 0.77 |
| ▸ | CA9 | Q16790 | 2/20 | 0.77 |
| ▸ | CA12 | O43570 | 1/20 | 0.77 |
| ▸ | BRD4 | O60885 | 1/20 | 0.77 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.77 |
| ▸ | MB | P02144 | 1/20 | 0.77 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.77 |
| ▸ | CA3 | P07451 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | RARG | P13631 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.77 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.77 |
| ▸ | CA4 | P22748 | 1/20 | 0.77 |
| ▸ | CA7 | P43166 | 1/20 | 0.77 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6516221 | 0.92 | KMT2A (0.73) | KMT2AMEN1MAPTALDH1A1CA1 | |
| Acetaminophen SCHEMBL8937727 | 0.88 | KMT2A (1.00) | KMT2AMEN1MAPTALDH1A1CA1 | |
| Acetaminophen SCHEMBL252939 | 0.88 | KMT2A (1.00) | KMT2AMEN1MAPTALDH1A1CA1 | |
| Acetaminophen SCHEMBL3480 | 0.88 | KMT2A (1.00) | KMT2AMEN1MAPTALDH1A1CA1 | |
| SCHEMBL18826484 | 0.86 | KMT2A (0.66) | KMT2AMEN1MAPTALDH1A1CA1 | |
| Acetaminophen SCHEMBL29086803 | 0.86 | KMT2A (0.87) | KMT2AMEN1MAPTALDH1A1CA1 | |
| Acetaminophen SCHEMBL5081499 | 0.86 | KMT2A (0.95) | KMT2AMEN1MAPTALDH1A1CA1 | |
| Acetaminophen SCHEMBL8959271 | 0.86 | KMT2A (0.95) | KMT2AMEN1MAPTALDH1A1CA1 | |
| Acetaminophen SCHEMBL20541508 | 0.86 | ALDH1A1 (0.95) | KMT2AMEN1MAPTALDH1A1CA1 | |
| Acetaminophen SCHEMBL10325382 | 0.86 | KMT2A (0.95) | KMT2AMEN1MAPTALDH1A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217031-B2 | Heteroaryl derivatives | NIPPON SHINYAKU CO., LTD. (JP) | 2012-07-10 | — | — | US | disclosed |
| US-20100048537-A1 | HETEROARYL DERIVATIVES | NIPPON SHINYAKU CO., LTD. (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2141168-A1 | HETEROARYL DERIVATIVES | Nippon Shinyaku Co., Ltd. (JP) | 2010-01-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048537-A1 | HETEROARYL DERIVATIVES | OPRD1, OPRM1, OPRK1 | KMT2A 1371/4885MEN1 3895/4885MAPT 2608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.