Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27984555 | 0.87 | ELANE (0.37) | USP2SMN1; SMN2GPR119ESR2ALDH1A1 | |
| SCHEMBL29100795 | 0.77 | ESR2 (0.34) | USP2SMN1; SMN2GPR119ESR2GRM5 | |
| SCHEMBL20548916 | 0.72 | GPR119 (0.33) | GPR119ESR2GRM5NR1H2 | |
| SCHEMBL2980997 | 0.72 | ESR2 (0.43) | USP2SMN1; SMN2GPR119ESR2ALDH1A1 | |
| SCHEMBL17481737 | 0.72 | USP2 (0.41) | USP2SMN1; SMN2GPR119ESR2ALDH1A1 | |
| SCHEMBL28686795 | 0.71 | ESR2 (0.34) | USP2SMN1; SMN2GPR119ESR2GRM5 | |
| SCHEMBL29877296 | 0.71 | ESR2 (0.40) | USP2SMN1; SMN2GPR119ESR2ALDH1A1 | |
| SCHEMBL28603592 | 0.70 | USP2 (0.39) | USP2SMN1; SMN2GPR119ESR2GRM5 | |
| SCHEMBL28655779 | 0.70 | NR1H2 (0.38) | USP2SMN1; SMN2GPR119ESR2GRM5 | |
| SCHEMBL20690515 | 0.70 | ALDH1A1 (0.40) | USP2SMN1; SMN2GPR119ESR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116041346-A | Amine-substituted heterocyclic compounds as EHMT2 inhibitors and methods of use thereof | EPIZYME股份有限公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-110088099-B | Amine-substituted heterocyclic compounds as EHMT2 inhibitors and methods of use thereof | EPIZYME股份有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-113939295-A | Pyridazinones and methods of use thereof | 金翅雀生物公司 | 2022-01-14 | — | — | CN | disclosed |
| CN-113767101-A | Novel indole-2-carboxamides having anti-Hepatitis B Virus (HBV) activity | 艾库里斯有限及两合公司 | 2021-12-07 | — | — | CN | disclosed |
| CN-113767102-A | Novel phenyl and pyridylureas having activity against Hepatitis B Virus (HBV) | 艾库里斯有限及两合公司 | 2021-12-07 | — | — | CN | disclosed |
| CN-112969702-A | Urea 6, 7-dihydro-4H-pyrazolo [4,3-c ] pyridine active agents against hepatitis b virus HBV | 艾库里斯有限及两合公司 | 2021-06-15 | — | — | CN | disclosed |
| CN-111527087-A | Novel highly active pyrazolo-piperidine substituted indole-2-carboxamides having activity against Hepatitis B Virus (HBV) | 艾库里斯有限及两合公司 | 2020-08-11 | — | — | CN | disclosed |