Sugi Predict

Sugi Predict / Compounds / SCHEMBL9894437

SCHEMBL9894437

SCHEMBL9894437

O=C(O)c1cnc(-c2cccnc2)n(-c2ccccc2)c1=O

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 6/20 0.50
▸ ALDH1A1 P00352 3/20 0.47
▸ MEN1 O00255 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ G6PD P11413 2/20 0.46
▸ CYP1A2 P05177 1/20 0.46
▸ POLB P06746 1/20 0.46
▸ CYP3A4 P08684 1/20 0.46
▸ CYP2C9 P11712 1/20 0.46
▸ CYP2C19 P33261 1/20 0.46
▸ L3MBTL1 Q9Y468 2/20 0.45
▸ KMO O15229 1/20 0.44
▸ MKNK1 Q9BUB5 1/20 0.42
▸ MKNK2 Q9HBH9 1/20 0.42
▸ MDM2 Q00987 1/20 0.42
▸ NPC1 O15118 1/20 0.41
▸ RAB9A P51151 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29288019 0.90 MAPT (0.48) MAPTALDH1A1MEN1KMT2AG6PD
SCHEMBL30672492 0.90 MAPT (0.48) MAPTALDH1A1MEN1KMT2AG6PD
SCHEMBL461803 0.89 HTT (0.49) MAPTALDH1A1MEN1KMT2ACYP1A2
SCHEMBL9893973 0.85 NPC1 (0.59) MAPTALDH1A1MEN1KMT2AG6PD
SCHEMBL455086 0.80 MAPT (0.42) MAPTALDH1A1MEN1KMT2AG6PD
SCHEMBL9895124 0.79 G6PD (0.41) MAPTALDH1A1MEN1KMT2AG6PD
SCHEMBL29288018 0.77 MAPT (0.46) MAPTALDH1A1MEN1KMT2AG6PD
SCHEMBL25208501 0.75 STAT1 (0.49) MAPTALDH1A1MEN1KMT2APOLB
SCHEMBL28453066 0.75 CYP1A2 (0.50) MAPTALDH1A1KMT2ACYP1A2POLB
SCHEMBL25663120 0.73 MAPT (0.80) MAPTALDH1A1MEN1KMT2AG6PD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260042765-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORP (US) 2026-02-12 — — US disclosed
US-12415809-B2 Pyrrolotriazine compounds as tam inhibitors INCYTE CORPORATION (US) 2025-09-16 — — US disclosed
CN-114456175-B Pyrrolotriazine compounds as TAM inhibitors 因赛特公司 2024-09-03 — — CN disclosed
CN-114456176-B Pyrrolotriazine compounds as TAM inhibitors 因赛特公司 2024-08-30 — — CN disclosed
US-20240124463-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORPORATION 2024-04-18 — — US disclosed
EP-4321513-A2 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS Incyte Corporation (US) 2024-02-14 — — EP disclosed
EP-3436461-B1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORP (US) 2023-11-01 — — EP disclosed
EP-3436461-B1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORP (US) 2023-11-01 — — EP disclosed
US-11591338-B2 Pyrrolotriazine compounds as TAM inhibitors INCYTE CORPORATION (US) 2023-02-28 — — US disclosed
CN-114456176-A Pyrrolotriazine compounds as TAM inhibitors 因赛特公司 2022-05-10 — — CN disclosed
WO-2017172596-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORPORATION (US) 2017-10-05 — — WO disclosed
US-20170275290-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS INCYTE CORPORATION 2017-09-28 — — US disclosed
US-9630928-B2 Intermediates to prepare herbicidal pyrimidone derivatives E. I. DU PONT DE NEMOURS AND COMPANY (US) 2017-04-25 — — US disclosed
EP-2475654-B1 HERBICIDAL PYRIMIDONE DERIVATIVES DU PONT (US) 2016-12-28 — — EP disclosed
US-20160024020-A1 INTERMEDIATES TO PREPARE HERBICIDAL PYRIMIDONE DERIVATIVES FMC CORPORATION 2016-01-28 — — US disclosed
US-9187432-B2 Intermediates to prepare herbicidal pyrimidone derivatives E I DU PONT DE NEMOURS AND COMPANY (US) 2015-11-17 — — US disclosed
US-20150105549-A1 INTERMEDIATES TO PREPARE HERBICIDAL PYRIMIDONE DERIVATIVES FMC CORPORATION 2015-04-16 — — US disclosed
US-8952024-B2 Herbicidal pyrimidone derivatives E I DU PONT DE NEMOURS AND COMPANY (US) 2015-02-10 — — US disclosed
CN-102596933-B Herbicidal pyrimidone derivatives DU PONT 2014-09-17 — — CN disclosed
US-20120149573-A1 HERBICIDAL BUS-NITROGEN-CONTAINING OXO AND SULFONO HETEROCYCLES FMC CORPORATION 2012-06-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260042765-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS MAP2K2, TTK, MAP2K5 MAPT 3577/4885ALDH1A1 2069/4885MEN1 1422/4885
US-20120149573-A1 HERBICIDAL BUS-NITROGEN-CONTAINING OXO AND SULFONO HETEROCYCLES CBR3, CYP1B1, CBR1 MAPT 4805/4885ALDH1A1 1886/4885MEN1 4318/4885
US-20170275290-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS MERTK, MAP3K15, MAP3K5 MAPT 3032/4885ALDH1A1 2279/4885MEN1 1951/4885
US-20150105549-A1 INTERMEDIATES TO PREPARE HERBICIDAL PYRIMIDONE DERIVATIVES CBR3, CBR1, MSRB3 MAPT 4761/4885ALDH1A1 1015/4885MEN1 4575/4885
US-12415809-B2 Pyrrolotriazine compounds as tam inhibitors MERTK, MAP3K15, MAP3K5 MAPT 3032/4885ALDH1A1 2279/4885MEN1 1951/4885
US-11591338-B2 Pyrrolotriazine compounds as TAM inhibitors MERTK, MAP3K15, MAP3K5 MAPT 3032/4885ALDH1A1 2279/4885MEN1 1951/4885
US-20160024020-A1 INTERMEDIATES TO PREPARE HERBICIDAL PYRIMIDONE DERIVATIVES CBR3, CBR1, PNPO MAPT 4753/4885ALDH1A1 830/4885MEN1 4505/4885
US-20240124463-A1 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS MERTK, MAP3K15, MAP3K5 MAPT 3032/4885ALDH1A1 2279/4885MEN1 1951/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.