Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15927301 | 0.77 | TAAR1 (0.41) | MEN1CYP3A4CYP2D6KMT2A | |
| SCHEMBL2839704 | 0.69 | GID4 (0.34) | — | |
| SCHEMBL2841800 | 0.65 | HTR1A (0.31) | — | |
| SCHEMBL3922304 | 0.64 | MEN1 (0.56) | MEN1CYP3A4CYP2D6KMT2A | |
| SCHEMBL31062493 | 0.64 | MEN1 (0.56) | MEN1CYP3A4CYP2D6KMT2A | |
| SCHEMBL2840034 | 0.63 | SLC6A2 (0.39) | CYP2D6 | |
| SCHEMBL21591682 | 0.63 | MEN1 (0.35) | MEN1CYP3A4CYP2D6KMT2A | |
| Hydrochloric Acid SCHEMBL10957229 | 0.63 | MEN1 (0.55) | MEN1CYP3A4CYP2D6KMT2A | |
| Hydrochloric Acid SCHEMBL29457654 | 0.63 | MEN1 (0.55) | MEN1CYP3A4CYP2D6KMT2A | |
| SCHEMBL2839565 | 0.61 | PNMT (0.42) | MEN1CYP3A4CYP2D6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217031-B2 | Heteroaryl derivatives | NIPPON SHINYAKU CO., LTD. (JP) | 2012-07-10 | — | — | US | disclosed |
| US-20100048537-A1 | HETEROARYL DERIVATIVES | NIPPON SHINYAKU CO., LTD. (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2141168-A1 | HETEROARYL DERIVATIVES | Nippon Shinyaku Co., Ltd. (JP) | 2010-01-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048537-A1 | HETEROARYL DERIVATIVES | OPRD1, OPRM1, OPRK1 | MEN1 3895/4885CYP3A4 1391/4885CYP2D6 352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.