Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 8/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL669121 | 0.72 | NNMT (0.52) | NNMTSMN1; SMN2LMNAKDM4EL3MBTL1 | |
| SCHEMBL3407188 | 0.71 | NNMT (0.56) | NNMTSMN1; SMN2LMNAKDM4EL3MBTL1 | |
| SCHEMBL31375669 | 0.71 | NNMT (0.43) | NNMTSMN1; SMN2LMNAHPGDSHDAC3 | |
| SCHEMBL30801502 | 0.70 | HDAC1 (0.64) | NNMTHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL30801504 | 0.70 | HDAC1 (0.68) | NNMTHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL25270597 | 0.70 | GABRP (0.43) | LMNA | |
| SCHEMBL18590902 | 0.69 | CHRNA7 (0.34) | — | |
| SCHEMBL28131949 | 0.69 | MKNK1 (0.41) | NNMTSIRT6 | |
| SCHEMBL587813 | 0.69 | KDM4E (0.34) | KDM4E | |
| SCHEMBL30873312 | 0.68 | HDAC1 (0.54) | NNMTHDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111499580-A | Substituted diaminocarboxamides and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith | 西格诺药品有限公司 | 2020-08-07 | — | — | CN | disclosed |