Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | STAT3 | P40763 | 4/20 | 0.56 |
| ▸ | CDC25B | P30305 | 2/20 | 0.47 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.47 |
| ▸ | CDC25A | P30304 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | S100A4 | P26447 | 3/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | APAF1 | O14727 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18391645 | 0.80 | TDP2 (0.46) | CDC25BKMT2AMEN1S100A4ATG4B | |
| SCHEMBL6577994 | 0.76 | STAT3 (0.61) | ALDH1A1STAT3CDC25BCDC25AKMT2A | |
| SCHEMBL30422 | 0.73 | STAT3 (0.57) | ALDH1A1STAT3CDC25BKMT2AMEN1 | |
| SCHEMBL29365382 | 0.73 | STAT3 (0.69) | ALDH1A1STAT3CDC25BKMT2AMEN1 | |
| SCHEMBL1887185 | 0.73 | STAT3 (0.69) | ALDH1A1STAT3CDC25BKMT2AMEN1 | |
| SCHEMBL16167166 | 0.72 | STAT3 (0.56) | ALDH1A1STAT3CDC25BKMT2AMEN1 | |
| SCHEMBL28705 | 0.72 | STAT3 (0.56) | ALDH1A1STAT3CDC25BKMT2AMEN1 | |
| SCHEMBL45695 | 0.71 | STAT3 (0.56) | ALDH1A1STAT3CDC25BKMT2AMEN1 | |
| SCHEMBL22325627 | 0.71 | ALDH1A1 (0.56) | ALDH1A1STAT3CDC25BCDC25AKMT2A | |
| SCHEMBL1885714 | 0.71 | ALDH1A1 (0.56) | ALDH1A1STAT3CDC25BKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109206390-B | Furanaphthoquinone-based sulfoximine derivative and application thereof in manufacturing STAT3 inhibitor | 北京大学 | 2021-04-27 | — | — | CN | disclosed |
| US-9150530-B2 | Esters of 4, 9-dihydroxy-naphtho [2, 3-b] furans for disease therapies | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2015-10-06 | — | — | US | disclosed |
| US-8871802-B2 | Naphthoquinones for disease therapies | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| EP-2681203-A1 | NOVEL ESTERS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR DISEASE THERAPIES | Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. (CN) | 2014-01-08 | — | — | EP | disclosed |
| US-20130345176-A1 | NOVEL ESTERS OF 4, 9-DIHYDROXY-NAPHTHO [2, 3-b] FURANS FOR DISEASE THERAPIES | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2013-12-26 | — | — | US | disclosed |
| US-20130150437-A1 | NAPHTHOQUINONES FOR DISEASE THERAPIES | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2013-06-13 | — | — | US | disclosed |
| WO-2012119265-A1 | NOVEL ESTERS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR DISEASE THERAPIES | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012024818-A1 | NOVEL ANPHTHOQUINONES FOR DISEASE THERAPIES | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130345176-A1 | NOVEL ESTERS OF 4, 9-DIHYDROXY-NAPHTHO [2, 3-b] FURANS FOR DISEASE THERAPIES | CYP46A1, HSD3B2, HSD3B1 | ALDH1A1 114/4885STAT3 3344/4885CDC25B 1092/4885 |
| US-20130150437-A1 | NAPHTHOQUINONES FOR DISEASE THERAPIES | NQO1, NME2, CYP27B1 | ALDH1A1 282/4885STAT3 1764/4885CDC25B 358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.