SCHEMBL2849367

SCHEMBL2849367

Nc1c(-c2ccccc2)cc(C(F)(F)F)c(N)c1C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 6/20 0.40
BACE1 P56817 2/20 0.38
GLA P06280 1/20 0.37
POLB P06746 1/20 0.37
GAA P10253 1/20 0.37
TSHR P16473 1/20 0.37
ADORA3 P0DMS8 1/20 0.37
ADORA2A P29274 1/20 0.37
ADORA1 P30542 1/20 0.37
HSD17B10 Q99714 2/20 0.37
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.36
MET P08581 1/20 0.36
NPC1 O15118 1/20 0.35
HPGD P15428 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
KIF11 P52732 1/20 0.35
S1PR1 P21453 1/20 0.35
S1PR3 Q99500 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2202989 0.86 ACHE (0.40) ACHEBACE1GLAPOLBGAA
SCHEMBL29266608 0.86 ACHE (0.40) ACHEBACE1GLAPOLBGAA
SCHEMBL8433508 0.81 KIF11 (0.41) ACHEBACE1GLAPOLBGAA
SCHEMBL27920522 0.80 GLA (0.38) ACHEBACE1GLAPOLBGAA
SCHEMBL27974154 0.80 GLA (0.47) ACHEBACE1GLAPOLBGAA
SCHEMBL28674664 0.79 KIF11 (0.46) ACHEBACE1GLAPOLBGAA
SCHEMBL6067691 0.76 KIF11 (0.39) ACHEBACE1GLAGAATSHR
SCHEMBL13385838 0.75 KIF11 (0.47) BACE1GLAPOLBGAATSHR
SCHEMBL28480301 0.75 PDE4A (0.37) BACE1TSHRADORA3ADORA2AADORA1
SCHEMBL7211572 0.74 ALDH1A1 (0.43) ACHEPOLBGAATSHRADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114379176-A Low-dielectric polyimide composite sheet and preparation method thereof 哈尔滨工程大学 2022-04-22 CN claimed
CN-114379176-B Low-dielectric polyimide composite sheet and preparation method thereof 哈尔滨工程大学 2023-08-22 CN disclosed
CN-114379176-A Low-dielectric polyimide composite sheet and preparation method thereof 哈尔滨工程大学 2022-04-22 CN disclosed
US-20100086792-A1 POLYIMIDE PRECURSOR, ITS COMPOSITION AND POLYIMIDE LAMINATE ETERNAL CHEMICAL CO., LTD. (TW) 2010-04-08 US disclosed