Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4862184 | 0.77 | RYR2 (0.31) | RYR2 | |
| SCHEMBL9118593 | 0.77 | TSHR (0.33) | RYR2TSHR | |
| SCHEMBL7687194 | 0.67 | — | — | |
| SCHEMBL654620 | 0.67 | — | — | |
| SCHEMBL450053 | 0.65 | — | — | |
| SCHEMBL3074985 | 0.64 | ALDH1A1 (0.37) | RYR2KDM4EALDH1A1HPGD | |
| SCHEMBL28923936 | 0.63 | ALDH1A1 (0.34) | RYR2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL10580638 | 0.63 | ALDH1A1 (0.34) | RYR2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL3258469 | 0.62 | — | — | |
| SCHEMBL9149 | 0.62 | RYR2 (0.36) | RYR2KDM4EALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 259 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3245198-B1 | PYRROLIDINE DERIVATIVES AS ANGIOTENSIN II TYPE 2 ANTAGONISTS | NOVARTIS AG (CH) | 2020-03-11 | — | — | EP | claimed |
| US-10065943-B2 | Pyrrolidine derivatives as angiotensin II type 2 antagonists | NOVARTIS AG (CH) | 2018-09-04 | — | — | US | claimed |
| US-20170369473-A1 | PYRROLIDINE DERIVATIVES AS ANGIOTENSIN II TYPE 2 ANTAGONISTS | SPINIFEX PHARMACEUTICALS PTY LTD (AU) | 2017-12-28 | — | — | US | claimed |
| EP-3245198-A1 | PYRROLIDINE DERIVATIVES AS ANGIOTENSIN II TYPE 2 ANTAGONISTS | Novartis AG (CH) | 2017-11-22 | — | — | EP | claimed |
| WO-2016113668-A1 | PYRROLIDINE DERIVATIVES AS ANGIOTENSIN II TYPE 2 ANTAGONISTS | NOVARTIS AG (CH) | 2016-07-21 | — | — | WO | claimed |
| EP-0790983-A1 | PESTICIDAL PYRIDINE THIOAMIDES | Novartis AG (CH) | 1997-08-27 | — | — | EP | claimed |
| WO-1996014301-A1 | PESTICIDAL PYRIDINE THIOAMIDES | NOVARTIS AG (CH) | 1996-05-17 | — | — | WO | claimed |
| US-12037333-B2 | Pyridopyrazine and pyridotriazine inhibitors of influenza virus replication | COCRYSTAL PHARMA, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| EP-4380920-A1 | INHIBITORS FOR CORONAVIRUSES | Cocrystal Pharma, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| CN-118103351-A | Coronavirus inhibitors | 共晶制药公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-113286793-B | Inhibitors of influenza virus replication of pyrrolopyrazines and pyridotriazines | 共结晶制药公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-112638477-B | Pyrrolo [2,3-B ] pyridine derivatives as inhibitors of influenza virus replication | 共晶制药公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-112574191-B | Isoxazole heterocyclic compound and application thereof | 南京圣和药业股份有限公司 | 2024-01-23 | — | — | CN | disclosed |
| EP-1334973-A1 | PREVENTIVE OR THERAPEUTIC MEDICINES FOR DIABETES CONTAINING FUSED-HETEROCYCLE COMPOUNDS OR THEIR SALTS | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2003-08-13 | — | — | EP | disclosed |
| US-6596863-B2 | Matrix metalloproteinase inhibitor is useful as an anticancer agent, angiogenesis inhibitor, a tumor cell infiltration inhibitor or a tumor metastasis inhibitor; inflammatory diseases, osteoarthritis, rheumatoid arthritis | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2003-07-22 | — | — | US | disclosed |
| US-20020198184-A1 | Medical composition containing nitroetheneamine derivative or salt thereof as active constituent | ISHIHARA SANGYO KAISHA LTD. (JP) | 2002-12-26 | — | — | US | disclosed |
| US-6451792-B1 | MATRIX METALLOPROTEASE INHIBITORS | ISHIHARA SANGYO KAISHA LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1116486-A1 | MEDICAL COMPOSITION CONTAINING NITROETHENEAMINE DERIVATIVE OR SALT THEREOF AS ACTIVE CONSTITUENT | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2001-07-18 | — | — | EP | disclosed |
| EP-0790983-A1 | PESTICIDAL PYRIDINE THIOAMIDES | Novartis AG (CH) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996014301-A1 | PESTICIDAL PYRIDINE THIOAMIDES | NOVARTIS AG (CH) | 1996-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170369473-A1 | PYRROLIDINE DERIVATIVES AS ANGIOTENSIN II TYPE 2 ANTAGONISTS | AGTR2, AGTR1, AVPR2 | RYR2 196/4885KDM4E 3003/4885ALDH1A1 1954/4885 |
| US-10065943-B2 | Pyrrolidine derivatives as angiotensin II type 2 antagonists | AGTR2, AGTR1, ACE2 | RYR2 148/4885KDM4E 3419/4885ALDH1A1 2233/4885 |
| US-20020198184-A1 | Medical composition containing nitroetheneamine derivative or salt thereof as active constituent | NR3C2, NR3C1, CNR1 | RYR2 1261/4885KDM4E 3681/4885ALDH1A1 1194/4885 |
| US-12037333-B2 | Pyridopyrazine and pyridotriazine inhibitors of influenza virus replication | PLPBP, EIF2AK2, TYMP | RYR2 3444/4885KDM4E 1508/4885ALDH1A1 3955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.