Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | MDM4 | O15151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28508739 | 0.85 | MDM4 (0.47) | HTR7HTR6MDM4TP53MDM2 | |
| SCHEMBL28503037 | 0.84 | HTR7 (0.48) | HTR7HTR6MDM4TP53MDM2 | |
| SCHEMBL28505050 | 0.81 | NPC1 (0.46) | HTR7HTR6MDM4TP53MDM2 | |
| SCHEMBL28508740 | 0.81 | TP53 (0.52) | HTR7HTR6MDM4TP53MDM2 | |
| SCHEMBL28500486 | 0.81 | PRKACA (0.49) | HTR7HTR6MDM4TP53MDM2 | |
| SCHEMBL28507696 | 0.80 | SMN1; SMN2 (0.48) | HTR7HTR6MDM4TP53MDM2 | |
| SCHEMBL28506801 | 0.80 | TP53 (0.48) | HTR7HTR6MDM4TP53MDM2 | |
| SCHEMBL28904632 | 0.78 | MDM2 (0.60) | HTR7HTR6MDM4TP53MDM2 | |
| SCHEMBL28497886 | 0.77 | LMNA (0.40) | HTR7HTR6MDM4TP53MDM2 | |
| SCHEMBL28503127 | 0.77 | MDM4 (0.48) | HTR7HTR6MDM4TP53MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112174937-B | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-112174937-A | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2021-01-05 | — | — | CN | disclosed |